Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.68 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.68 |
| ▸ | NPC1 | O15118 | 1/20 | 0.68 |
| ▸ | XBP1 | P17861 | 1/20 | 0.68 |
| ▸ | RAB9A | P51151 | 1/20 | 0.68 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.68 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.68 |
| ▸ | ATM | Q13315 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | MITF | O75030 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30099697 | 1.00 | MAPT (0.68) | MAPTALDH1A1NPSR1LMNASMN1; SMN2 | |
| SCHEMBL3262089 | 0.81 | MAPT (1.00) | MAPTALDH1A1NPSR1LMNASMN1; SMN2 | |
| SCHEMBL29516939 | 0.81 | MAPT (1.00) | MAPTALDH1A1NPSR1LMNASMN1; SMN2 | |
| SCHEMBL13295325 | 0.81 | MAPT (0.56) | MAPTALDH1A1NPSR1LMNASMN1; SMN2 | |
| SCHEMBL11453080 | 0.79 | LMNA (0.65) | ALDH1A1NPSR1LMNAATMKMT2A | |
| SCHEMBL30583271 | 0.78 | ALDH1A1 (0.67) | MAPTALDH1A1LMNASMN1; SMN2NPC1 | |
| SCHEMBL5001108 | 0.78 | ALDH1A1 (0.67) | MAPTALDH1A1LMNASMN1; SMN2NPC1 | |
| SCHEMBL11455384 | 0.77 | MAPT (0.46) | MAPTALDH1A1NPSR1LMNASMN1; SMN2 | |
| SCHEMBL11445281 | 0.77 | MAPT (0.47) | MAPTALDH1A1NPSR1LMNASMN1; SMN2 | |
| SCHEMBL30541541 | 0.77 | FEN1 (0.50) | MAPTALDH1A1NPSR1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12600723-B2 | Tetracyclic compounds as DGK inhibitors | INCYTE CORPORATION (US) | 2026-04-14 | — | — | US | disclosed |
| US-20240034734-A1 | TETRACYCLIC COMPOUNDS AS DGK INHIBITORS | INCYTE CORPORATION | 2024-02-01 | — | — | US | disclosed |
| US-7732146-B2 | Method for screening an agent that modulates activity of macrophage migration inhibitory factor | AVANIR PHARMACEUTICALS (US) | 2010-06-08 | — | — | US | disclosed |
| US-7732146-B2 | Method for screening an agent that modulates activity of macrophage migration inhibitory factor | AVANIR PHARMACEUTICALS (US) | 2010-06-08 | — | — | US | disclosed |
| US-7732146-B2 | Method for screening an agent that modulates activity of macrophage migration inhibitory factor | AVANIR PHARMACEUTICALS (US) | 2010-06-08 | — | — | US | disclosed |
| EP-1389110-B1 | INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR AND METHODS FOR IDENTIFYING THE SAME | AVANIR PHARMACEUTICALS (US) | 2010-03-24 | — | — | EP | disclosed |
| EP-1389110-B1 | INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR AND METHODS FOR IDENTIFYING THE SAME | AVANIR PHARMACEUTICALS (US) | 2010-03-24 | — | — | EP | disclosed |
| US-7678909-B1 | 2-[2-(3-Amino-cyclohexyl)-5-benzyl-4-oxo-4,5-dihydro-imidazo[4,5-c]pyridin-3-ylmethyl]-benzonitrile; type 2 diabetes mellitus, diabetic dislipidemia, impaired glucose tolerance; female infertility, osteoporosis, male contraception and neurological disorders | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-03-16 | — | — | US | disclosed |
| US-7514225-B2 | Method for screening an agent that modulates activity of macrophage migration inhibitory factor | AVANIR PHARMACEUTICALS (US) | 2009-04-07 | — | — | US | disclosed |
| US-7514225-B2 | Method for screening an agent that modulates activity of macrophage migration inhibitory factor | AVANIR PHARMACEUTICALS (US) | 2009-04-07 | — | — | US | disclosed |
| US-20060194793-A1 | INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR AND METHODS FOR IDENTIFYING THE SAME | AVANIR PHARMACEUTICALS | 2006-08-31 | — | — | US | disclosed |
| US-20060194792-A1 | Inhibitors of macrophage migration inhibitory factor and methods for identifying the same | AVANIR PHARMACEUTICALS | 2006-08-31 | — | — | US | disclosed |
| US-7084141-B2 | Inhibitors of macrophase migration inhibitory factor and methods for identifying the same | AVANIR PHARMACEUTICALS (US) | 2006-08-01 | — | — | US | disclosed |
| US-20060094727-A1 | INHIBITORS OF MACROPHASE MIGRATION INHIBITORY FACTOR AND METHODS FOR IDENTIFYING THE SAME | AVANIR PHARMACEUTICALS | 2006-05-04 | — | — | US | disclosed |
| US-20050287617-A1 | Inhibitors of macrophage migration inhibitory factor and methods for identifying the same | AVANIR PHARMACEUTICALS | 2005-12-29 | — | — | US | disclosed |
| US-20050282236-A1 | Inhibitors of macrophage migration inhibitory factor and methods for identifying the same | AVANIR PHARMACEUTICALS | 2005-12-22 | — | — | US | disclosed |
| EP-1389110-A2 | INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR AND METHODS FOR IDENTIFYING THE SAME | Avanir Pharmaceuticals (US) | 2004-02-18 | — | — | EP | disclosed |
| US-20030195194-A1 | Inhibitors of macrophage migration inhibitory factor and methods for identifying the same | AVANIR PHARMACEUTICALS | 2003-10-16 | — | — | US | disclosed |
| WO-2002094203-A2 | INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR AND METHODS FOR IDENTIFYING THE SAME | AVANIR PHARMACEUTICALS (US) | 2002-11-28 | — | — | WO | disclosed |
| US-4192876-A | ANTIALLERGENS | SANDOZ, INC. (US) | 1980-03-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060094727-A1 | INHIBITORS OF MACROPHASE MIGRATION INHIBITORY FACTOR AND METHODS FOR IDENTIFYING THE SAME | MIF, MSR1, MMP12 | MAPT 4790/4885ALDH1A1 1637/4885NPSR1 563/4885 |
| US-20240034734-A1 | TETRACYCLIC COMPOUNDS AS DGK INHIBITORS | DGKA, DGKG, DGKI | MAPT 3354/4885ALDH1A1 3928/4885NPSR1 4801/4885 |
| US-20060194793-A1 | INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR AND METHODS FOR IDENTIFYING THE SAME | MIF, MSR1, MMP12 | MAPT 4805/4885ALDH1A1 2081/4885NPSR1 482/4885 |
| US-20030195194-A1 | Inhibitors of macrophage migration inhibitory factor and methods for identifying the same | MIF, MSR1, MMP12 | MAPT 4808/4885ALDH1A1 1863/4885NPSR1 707/4885 |
| US-12600723-B2 | Tetracyclic compounds as DGK inhibitors | DGKB, DGKA, NR2C2 | MAPT 4860/4885ALDH1A1 3817/4885NPSR1 412/4885 |
| US-20060194792-A1 | Inhibitors of macrophage migration inhibitory factor and methods for identifying the same | MIF, MSR1, MMP12 | MAPT 4805/4885ALDH1A1 2081/4885NPSR1 482/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.