Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 2/20 | 0.39 |
| ▸ | PARP1 | P09874 | 2/20 | 0.39 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.39 |
| ▸ | CLK1 | P49759 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 2/20 | 0.38 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CCND1 | P24385 | 1/20 | 0.37 |
| ▸ | CCND2 | P30279 | 1/20 | 0.37 |
| ▸ | CCND3 | P30281 | 1/20 | 0.37 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 2/20 | 0.37 |
| ▸ | CLK2 | P49760 | 1/20 | 0.37 |
| ▸ | CLK3 | P49761 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30101980 | 0.91 | PIK3CB (0.40) | DYRK1ACLK1PIM1IRAK4SYK | |
| SCHEMBL30101960 | 0.82 | PIM1 (0.37) | TNKSPARP1TNKS2DYRK1APIM1 | |
| SCHEMBL23925581 | 0.80 | SYK (0.42) | DYRK1ACLK1PIM1CDK4CCND1 | |
| SCHEMBL30101871 | 0.78 | PIK3CB (0.41) | DYRK1ACLK1PIM1ACVR1IRAK4 | |
| SCHEMBL31472806 | 0.76 | XDH (0.41) | DYRK1ACLK1PIM1ACVR1SYK | |
| SCHEMBL23925427 | 0.71 | SYK (0.44) | DYRK1ACLK1PIM1SYK | |
| SCHEMBL30101911 | 0.69 | JAK2 (0.40) | DYRK1ACLK1PIM1SYKCLK2 | |
| SCHEMBL31472809 | 0.69 | PIK3CA (0.48) | DYRK1ACLK1PIM1SYK | |
| SCHEMBL30101909 | 0.69 | AHR (0.39) | TNKSPARP1TNKS2PIM1 | |
| SCHEMBL30101920 | 0.69 | PIM1 (0.38) | TNKSPARP1TNKS2PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115443276-A | Pyridopyrimidinone derivatives and their use as modulators of aromatic hydrocarbon receptors | 东亚ST株式会社 | 2022-12-06 | — | — | CN | claimed |
| CN-115443276-A | Pyridopyrimidinone derivatives and their use as modulators of aromatic hydrocarbon receptors | 东亚ST株式会社 | 2022-12-06 | — | — | CN | disclosed |