Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.50 |
| ▸ | HTR3B | O95264 | 1/20 | 0.50 |
| ▸ | HTR3A | P46098 | 1/20 | 0.50 |
| ▸ | HTR5A | P47898 | 1/20 | 0.50 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.50 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.45 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.45 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.44 |
| ▸ | PIM1 | P11309 | 2/20 | 0.44 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.44 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.44 |
| ▸ | C1S | P09871 | 1/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.44 |
| ▸ | NCF1 | P14598 | 1/20 | 0.44 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30014605 | 0.78 | C1S (0.54) | HTR3EHTR3BHTR3AHTR5AHTR3D | |
| SCHEMBL30775562 | 0.77 | IP6K1 (0.76) | HTR2CTGFBR1ACVR1IP6K1ADRB1 | |
| Hydrochloric Acid SCHEMBL30575860 | 0.75 | IP6K1 (0.74) | HTR2CTGFBR1ACVR1IP6K1ADRB1 | |
| SCHEMBL6643085 | 0.74 | ADRB2 (0.56) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL15445062 | 0.72 | ADRB2 (0.62) | HTR3EHTR3BHTR3AHTR5AHTR3D | |
| SCHEMBL28291142 | 0.71 | HTR3E (0.63) | HTR3EHTR3BHTR3AHTR5AHTR3D | |
| SCHEMBL6017418 | 0.71 | HTR3E (0.63) | HTR3EHTR3BHTR3AHTR5AHTR3D | |
| SCHEMBL2419422 | 0.71 | HTR3E (0.63) | HTR3EHTR3BHTR3AHTR5AHTR3D | |
| SCHEMBL23999692 | 0.70 | NCF1 (0.48) | TGFBR1ACVR1IP6K1ADRB1PIM1 | |
| SCHEMBL7256928 | 0.70 | FGFR1 (0.53) | HTR3EHTR3BHTR3AHTR5AHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4110333-A1 | SOS1 INHIBITORS | Mirati Therapeutics, Inc. (US) | 2023-01-04 | — | — | EP | disclosed |