Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 7/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.45 |
| ▸ | RELA | Q04206 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.44 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.42 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29580473 | 1.00 | MRGPRX4 (0.45) | MRGPRX4TP53PKMNFKB1NFKB2 | |
| SCHEMBL3006290 | 0.87 | CYP4F2 (0.57) | MRGPRX4SMN1; SMN2SLC7A5FOLH1ACHE | |
| SCHEMBL4830438 | 0.86 | MEN1 (0.49) | MRGPRX4TP53PKMNFKB1NFKB2 | |
| SCHEMBL7458715 | 0.84 | MLYCD (0.50) | LTB4RLTB4R2L3MBTL1HTR2CSLC6A4 | |
| SCHEMBL3010204 | 0.84 | DRD2 (0.49) | ACHE | |
| SCHEMBL14426308 | 0.84 | LTB4R (0.49) | ACHERAB9ALTB4RLTB4R2L3MBTL1 | |
| SCHEMBL31505912 | 0.84 | DRD2 (0.49) | ACHE | |
| SCHEMBL379891 | 0.83 | ESRRG (0.47) | MEN1KMT2A | |
| SCHEMBL3005511 | 0.83 | CYP4F2 (0.43) | SMN1; SMN2SLC7A5ACHERAB9AMEN1 | |
| SCHEMBL3012969 | 0.83 | ALDH1A1 (0.47) | SMN1; SMN2SLC7A5ACHERAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250195462-A1 | SHORT ACTING PHENYLALKYLAMINE CALCIUM CHANNEL BLOCKERS AND USES THEREOF | MILESTONE PHARMACEUTICALS INC (CA) | 2025-06-19 | — | — | US | disclosed |
| US-20240366552-A1 | SHORT ACTING PHENYLALKYLAMINE CALCIUM CHANNEL BLOCKERS AND USES THEREOF | MILESTONE PHARMACEUTICALS INC (CA) | 2024-11-07 | — | — | US | disclosed |
| US-20240115543-A1 | SHORT ACTING PHENYLALKYLAMINE CALCIUM CHANNEL BLOCKERS AND USES THEREOF | MILESTONE PHARMACEUTICALS INC (CA) | 2024-04-11 | — | — | US | disclosed |
| US-20230255923-A1 | SHORT ACTING PHENYLALKYLAMINE CALCIUM CHANNEL BLOCKERS AND USES THEREOF | MILESTONE PHARMACEUTICALS INC (CA) | 2023-08-17 | — | — | US | disclosed |
| US-20220142963-A1 | SHORT ACTING PHENYLALKYLAMINE CALCIUM CHANNEL BLOCKERS AND USES THEREOF | MILESTONE PHARMACEUTICALS INC (CA) | 2022-05-12 | — | — | US | disclosed |
| CN-113694019-A | Highly water-soluble salts of short-acting phenylalkylamine calcium channel blockers and uses thereof | 里程医药有限公司 | 2021-11-26 | — | — | CN | disclosed |
| CN-107613970-B | Highly water-soluble salts of short-acting phenylalkylamine calcium channel blockers and uses thereof | 里程医药有限公司 | 2021-10-19 | — | — | CN | disclosed |
| US-20210315855-A1 | SHORT ACTING PHENYLALKYLAMINE CALCIUM CHANNEL BLOCKERS AND USES THEREOF | MILESTONE PHARMACEUTICALS INC (CA) | 2021-10-14 | — | — | US | disclosed |
| US-20210059972-A1 | SHORT ACTING PHENYLALKYLAMINE CALCIUM CHANNEL BLOCKERS AND USES THEREOF | MILESTONE PHARMACEUTICALS INC (CA) | 2021-03-04 | — | — | US | disclosed |
| US-20200230097-A1 | SHORT ACTING PHENYLALKYLAMINE CALCIUM CHANNEL BLOCKERS AND USES THEREOF | MILESTONE PHARMACEUTICALS INC (CA) | 2020-07-23 | — | — | US | disclosed |
| US-20160074354-A1 | SHORT ACTING PHENYLALKYLAMINE CALCIUM CHANNEL BLOCKERS AND USES THEREOF | ACQUIOM AGENCY SERVICES, LLC | 2016-03-17 | — | — | US | disclosed |
| US-9227918-B2 | Short acting phenylalkylamine calcium channel blockers and uses thereof | MILESTONE PHARMACEUTICALS (CA) | 2016-01-05 | — | — | US | disclosed |
| US-20140296335-A1 | SHORT ACTING PHENYLALKYLAMINE CALCIUM CHANNEL BLOCKERS AND USES THEREOF | ACQUIOM AGENCY SERVICES, LLC | 2014-10-02 | — | — | US | disclosed |
| EP-2170050-B1 | Short acting phenylalkylamine calcium channel blockers and uses thereof | MILESTONE PHARMACEUTICALS INC (CA) | 2014-06-18 | — | — | EP | disclosed |
| CN-102099344-B | Imidazole carboxamides | LILLY CO ELI | 2013-10-30 | — | — | CN | disclosed |
| CN-102099344-A | Imidazole carboxamides | LILLY CO ELI | 2011-06-15 | — | — | CN | disclosed |
| US-20100190852-A1 | SHORT ACTING PHENYLALKYLAMINE CALCIUM CHANNEL BLOCKERS AND USES THEREOF | MILESTONE PHARMACEUTICALS INC. (CA) | 2010-07-29 | — | — | US | disclosed |
| CN-101754678-A | Short-acting phenalkylamine calcium channel blockers and uses thereof | MILESTONE PHARMACEUTICALS INC | 2010-06-23 | — | — | CN | disclosed |
| EP-2170050-A1 | SHORT ACTING PHENYLALKYLAMINE CALCIUM CHANNEL BLOCKERS AND USES THEREOF | Milestone Pharmaceuticals Inc. (CA) | 2010-04-07 | — | — | EP | disclosed |
| WO-2008156820-A1 | SHORT ACTING PHENYLALKYLAMINE CALCIUM CHANNEL BLOCKERS AND USES THEREOF | MILESTONE PHARMACEUTICALS INC. (CA) | 2008-12-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200230097-A1 | SHORT ACTING PHENYLALKYLAMINE CALCIUM CHANNEL BLOCKERS AND USES THEREOF | ORAI1, ATP2A1, RYR2 | MRGPRX4 2280/4885TP53 4502/4885PKM 1127/4885 |
| US-20240115543-A1 | SHORT ACTING PHENYLALKYLAMINE CALCIUM CHANNEL BLOCKERS AND USES THEREOF | ORAI1, ATP2A1, RYR2 | MRGPRX4 2280/4885TP53 4502/4885PKM 1127/4885 |
| US-20220142963-A1 | SHORT ACTING PHENYLALKYLAMINE CALCIUM CHANNEL BLOCKERS AND USES THEREOF | ORAI1, ATP2A1, RYR2 | MRGPRX4 2280/4885TP53 4502/4885PKM 1127/4885 |
| US-20230255923-A1 | SHORT ACTING PHENYLALKYLAMINE CALCIUM CHANNEL BLOCKERS AND USES THEREOF | ORAI1, ATP2A1, RYR2 | MRGPRX4 2280/4885TP53 4502/4885PKM 1127/4885 |
| US-20240366552-A1 | SHORT ACTING PHENYLALKYLAMINE CALCIUM CHANNEL BLOCKERS AND USES THEREOF | ORAI1, ATP2A1, RYR2 | MRGPRX4 2280/4885TP53 4502/4885PKM 1127/4885 |
| US-20210315855-A1 | SHORT ACTING PHENYLALKYLAMINE CALCIUM CHANNEL BLOCKERS AND USES THEREOF | ORAI1, ATP2A1, RYR2 | MRGPRX4 2280/4885TP53 4502/4885PKM 1127/4885 |
| US-20210059972-A1 | SHORT ACTING PHENYLALKYLAMINE CALCIUM CHANNEL BLOCKERS AND USES THEREOF | ORAI1, ATP2A1, RYR2 | MRGPRX4 2280/4885TP53 4502/4885PKM 1127/4885 |
| US-20140296335-A1 | SHORT ACTING PHENYLALKYLAMINE CALCIUM CHANNEL BLOCKERS AND USES THEREOF | ORAI1, ATP2A1, RYR2 | MRGPRX4 2280/4885TP53 4502/4885PKM 1127/4885 |
| US-20160074354-A1 | SHORT ACTING PHENYLALKYLAMINE CALCIUM CHANNEL BLOCKERS AND USES THEREOF | ORAI1, ATP2A1, RYR2 | MRGPRX4 2280/4885TP53 4502/4885PKM 1127/4885 |
| US-20100190852-A1 | SHORT ACTING PHENYLALKYLAMINE CALCIUM CHANNEL BLOCKERS AND USES THEREOF | ORAI1, ATP2A1, RYR2 | MRGPRX4 2280/4885TP53 4502/4885PKM 1127/4885 |
| US-20250195462-A1 | SHORT ACTING PHENYLALKYLAMINE CALCIUM CHANNEL BLOCKERS AND USES THEREOF | ORAI1, ATP2A1, RYR2 | MRGPRX4 2280/4885TP53 4502/4885PKM 1127/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.