Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MGLL | Q99685 | 1/20 | 0.31 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3095800 | 0.82 | LMNA (0.47) | KMT2ALMNAELANEADRB3 | |
| SCHEMBL16886284 | 0.80 | KCNN4 (0.34) | ELANEADRB3 | |
| SCHEMBL10473438 | 0.78 | ELANE (0.33) | KMT2ALMNAELANEADRB3 | |
| SCHEMBL26668633 | 0.76 | NOS1 (0.38) | KMT2AELANEADRB3 | |
| SCHEMBL26668132 | 0.74 | KCNN4 (0.34) | ELANEADRB3 | |
| SCHEMBL16422823 | 0.74 | ELANE (0.32) | ELANEADRB3 | |
| SCHEMBL30107368 | 0.73 | ADRB3 (0.37) | ELANEADRB3 | |
| SCHEMBL16867683 | 0.71 | NOS1 (0.45) | — | |
| SCHEMBL18704852 | 0.70 | LMNA (0.33) | LMNA | |
| SCHEMBL3372959 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110678466-B | Diazanaphthalenes as HPK1 inhibitors | 豪夫迈·罗氏有限公司 | 2023-01-31 | — | — | CN | disclosed |