Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.65 |
| ▸ | GRM8 | O00222 | 1/20 | 0.65 |
| ▸ | GRM6 | O15303 | 1/20 | 0.65 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.65 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.65 |
| ▸ | GSR | P00390 | 1/20 | 0.65 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.65 |
| ▸ | GRM5 | P41594 | 1/20 | 0.65 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.65 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.65 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.65 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.65 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.65 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.65 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.65 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.65 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.65 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.65 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.65 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30978878 | 0.85 | CYP1A2 (0.65) | CYP1A2GRM8GRM6GRIN2DGRIN3B | |
| SCHEMBL900033 | 0.83 | GRM8 (0.62) | CYP1A2GRM8GRM6GRIN2DGRIN3B | |
| SCHEMBL301074 | 0.83 | ALOX15 (0.67) | CYP1A2GRM8GRM6GRIN2DGRIN3B | |
| SCHEMBL15672142 | 0.81 | CYP1A2 (0.60) | CYP1A2GRM8GRM6GRIN2DGRIN3B | |
| SCHEMBL16900192 | 0.81 | GRM8 (0.60) | CYP1A2GRM8GRM6GRIN2DGRIN3B | |
| SCHEMBL16541568 | 0.81 | CYP1A2 (0.60) | CYP1A2GRM8GRM6GRIN2DGRIN3B | |
| SCHEMBL16204518 | 0.81 | BLM (0.64) | CYP1A2GRM8GRM6GRIN2DGRIN3B | |
| SCHEMBL5842267 | 0.80 | CYP1A2 (0.65) | CYP1A2GRM8GRM6GRIN2DGRIN3B | |
| Glutamic Acid SCHEMBL5823746 | 0.80 | GRM8 (0.90) | CYP1A2GRM8GRM6GRIN2DGRIN3B | |
| D-Glutamate SCHEMBL5823743 | 0.80 | GRM8 (0.90) | CYP1A2GRM8GRM6GRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2272951-B1 | Vitamin k epoxide recycling polypeptide vkorc1, a therapeutic target of coumarin and their derivatives | BAXTER INT (US) | 2014-07-23 | — | — | EP | claimed |
| EP-2189523-B1 | Vitamin K epoxide recycling polypeptide VKORC1, a therapeutic target of coumarin and their derivatives | BAXTER INT (US) | 2012-01-04 | — | — | EP | claimed |
| EP-2272951-A1 | Vitamin k epoxide recycling polypeptide vkorc1, a therapeutic target of coumarin and their derivatives | Baxter International Inc (US) | 2011-01-12 | — | — | EP | claimed |
| EP-2189523-A1 | Vitamin K epoxide recycling polypeptide VKORC1, a therapeutic target of coumarin and their derivatives | Baxter International Inc. (US) | 2010-05-26 | — | — | EP | claimed |
| US-5116730-A | AMINO ACID SUBSTITUTED 4-AMINOPHENAZONES FOR MEASURING ENZYME ACTIVITY | BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY (US) | 1992-05-26 | — | — | US | claimed |
| EP-0346870-A2 | Novel amino acid substituted 4-aminophenazones for measuring enzyme activity | THE BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY (US) | 1989-12-20 | — | — | EP | claimed |
| US-20200217281-A1 | SYSTEM AND METHOD FOR ON-BOARD ELECTROCHEMICAL UPGRADING OF HYDROCARBON FUELS | SAUDI ARABIAN OIL COMPANY (SA) | 2020-07-09 | — | — | US | disclosed |
| CN-101090977-B | Tripeptide and tetrapeptide thioethers | TELIK INC | 2013-04-10 | — | — | CN | disclosed |
| US-7777046-B2 | Method of synthesis of a salt of N-acetyl-L-cysteinylcobalamin | KENT STATE UNIVERSITY (US) | 2010-08-17 | — | — | US | disclosed |
| WO-2009062136-A2 | CONTROLLED DELIVERY OF INSULIN FROM THERMO-SENSITIVE POLYMER SOLUTION | NDSU RESEARCH FOUNDATION (US) | 2009-05-14 | — | — | WO | disclosed |
| EP-1833978-B1 | TRIPEPTIDE AND TETRAPEPTIDE THIOETHERS | TELIK INC (US) | 2008-10-08 | — | — | EP | disclosed |
| US-20080234489-A1 | Method of synthesis of the sodium salt of N-acetyl-L-cysteinylcobalamin | KENT STATE UNIVERSITY | 2008-09-25 | — | — | US | disclosed |
| CN-101090977-A | Tripeptide and tetrapeptide thioethers | TELIK INC (US) | 2007-12-19 | — | — | CN | disclosed |
| US-5607659-A | Directed biodistribution of radiolabelled biotin using carbohydrate polymers | NEORX CORPORATION (US) | 1997-03-04 | — | — | US | disclosed |
| WO-1996034966-A2 | ENGINEERING PROTEIN POSTTRANSLATIONAL MODIFICATION IN TRANSGENIC ORGANISMS | AMERICAN RED CROSS (US) | 1996-11-07 | — | — | WO | disclosed |
| EP-0683676-A1 | DIRECTED BIODISTRIBUTION OF SMALL MOLECULES | NEORX CORPORATION (US) | 1995-11-29 | — | — | EP | disclosed |
| WO-1994017829-A1 | DIRECTED BIODISTRIBUTION OF SMALL MOLECULES | NEORX CORPORATION (US) | 1994-08-18 | — | — | WO | disclosed |
| US-5116730-A | AMINO ACID SUBSTITUTED 4-AMINOPHENAZONES FOR MEASURING ENZYME ACTIVITY | BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY (US) | 1992-05-26 | — | — | US | disclosed |
| US-5081259-A | Novel amino acid substituted 4-aminophenazones for measuring enzyme activity | ABBOTT LABORATORIES (US) | 1992-01-14 | — | — | US | disclosed |
| EP-0346870-A2 | Novel amino acid substituted 4-aminophenazones for measuring enzyme activity | THE BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY (US) | 1989-12-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080234489-A1 | Method of synthesis of the sodium salt of N-acetyl-L-cysteinylcobalamin | MMAB, CBS, NCLN | CYP1A2 2969/4885GRM8 4388/4885GRM6 3818/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.