Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.42 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | USP7 | Q93009 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TNF | P01375 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24752971 | 1.00 | GPR119 (0.42) | GPR119HCAR1MCL1PIK3CDPIK3CA | |
| SCHEMBL24542863 | 0.86 | ACHE (0.46) | GPR119HCAR1USP7 | |
| SCHEMBL31548396 | 0.83 | USP7 (0.50) | GPR119HCAR1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL30120142 | 0.82 | HCAR1 (0.41) | GPR119HCAR1MCL1PIK3CDPIK3CA | |
| SCHEMBL24752951 | 0.82 | HCAR1 (0.41) | GPR119HCAR1MCL1PIK3CDPIK3CA | |
| SCHEMBL24542757 | 0.82 | IDO1 (0.44) | HCAR1POLBSMN1; SMN2TNF | |
| SCHEMBL24542759 | 0.81 | BACE1 (0.45) | HCAR1PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL30120107 | 0.81 | BRAF (0.45) | GPR119DPP4 | |
| SCHEMBL24752970 | 0.81 | BRAF (0.45) | GPR119DPP4 | |
| SCHEMBL24753270 | 0.80 | HCAR1 (0.41) | GPR119HCAR1PIK3CDPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4351583-A1 | THERAPEUTICS FOR THE DEGRADATION OF MUTANT BRAF | C4 Therapeutics, Inc. (US) | 2024-04-17 | — | — | EP | disclosed |
| WO-2022261250-A1 | THERAPEUTICS FOR THE DEGRADATION OF MUTANT BRAF | C4 THERAPEUTICS, INC. (US) | 2022-12-15 | — | — | WO | disclosed |