Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.52 |
| ▸ | P2RX7 | Q99572 | 6/20 | 0.48 |
| ▸ | POLQ | O75417 | 1/20 | 0.48 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | RXRB | P28702 | 1/20 | 0.43 |
| ▸ | RXRG | P48443 | 1/20 | 0.43 |
| ▸ | CMA1 | P23946 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4324874 | 0.85 | P2RX7 (0.50) | PTGS2P2RX7POLQTAS2R14TDP1 | |
| Methyl Alcohol SCHEMBL8011354 | 0.82 | POLQ (0.62) | PTGS2POLQAKR1B1TDP1KDM4E | |
| SCHEMBL29718585 | 0.82 | POLQ (0.61) | PTGS2POLQAKR1B1TDP1KDM4E | |
| SCHEMBL187791 | 0.82 | POLQ (0.61) | PTGS2POLQAKR1B1TDP1KDM4E | |
| SCHEMBL30428048 | 0.81 | PTGS2 (0.54) | PTGS2POLQAKR1B1TDP1KDM4E | |
| SCHEMBL2429479 | 0.81 | PTGS2 (0.54) | PTGS2POLQAKR1B1TDP1KDM4E | |
| SCHEMBL29525642 | 0.81 | PTGS2 (0.57) | PTGS2P2RX7POLQAKR1B1TDP1 | |
| SCHEMBL305056 | 0.81 | PTGS2 (0.57) | PTGS2P2RX7POLQAKR1B1TDP1 | |
| Hydrochloric Acid SCHEMBL2529825 | 0.80 | POLQ (0.59) | PTGS2POLQAKR1B1TDP1KDM4E | |
| SCHEMBL11967099 | 0.80 | GABRA1 (0.46) | P2RX7POLQTAS2R14TDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022212326-A1 | NEK7 INHIBITORS | Halia Therapeutics, Inc. (US) | 2022-10-06 | — | — | WO | disclosed |