Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 5/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | GSK3A | P49840 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 3/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | FGF23 | Q9GZV9 | 1/20 | 0.31 |
| ▸ | HAO1 | Q9UJM8 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23887755 | 0.77 | MAOB (0.39) | HPGDALDH1A1MAPTKMT2AGAA | |
| SCHEMBL30367984 | 0.77 | MAOB (0.39) | HPGDALDH1A1MAPTKMT2AGAA | |
| SCHEMBL25195489 | 0.73 | RAB9A (0.38) | HPGDALDH1A1LMNAKDM4EMEN1 | |
| SCHEMBL23896349 | 0.73 | RAB9A (0.38) | HPGDALDH1A1LMNAKDM4EMEN1 | |
| SCHEMBL30121047 | 0.71 | HAO1 (0.41) | HPGDALDH1A1KDM4EMAPTHAO1 | |
| SCHEMBL23887737 | 0.69 | RAB9A (0.39) | HPGDALDH1A1LMNAKDM4EMEN1 | |
| SCHEMBL29958070 | 0.68 | LMNA (0.43) | HPGDALDH1A1LMNAMEN1MAPT | |
| SCHEMBL30134875 | 0.68 | LMNA (0.43) | HPGDALDH1A1LMNAMEN1MAPT | |
| SCHEMBL28789381 | 0.68 | HAO1 (0.45) | HPGDALDH1A1LMNAMEN1MAPT | |
| SCHEMBL29798255 | 0.66 | HPGD (0.43) | HPGDALDH1A1LMNAMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4126819-A1 | 7- OR 8-HYDROXY-ISOQUINOLINE AND 7- OR 8-HYDROXY-QUINOLINE DERIVATIVES AS ALPHA-1 -ANTITRYPSIN MODULATORS FOR TREATING ALPHA-1 -ANTITRYPSIN DEFICIENCY (AATD) | Vertex Pharmaceuticals Incorporated (US) | 2023-02-08 | — | — | EP | disclosed |