Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 3/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.47 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.47 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | RAPGEF4 | Q8WZA2 | 6/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20310 | 0.86 | F2 (0.50) | F2PRSS1PRSS2PRSS3CA1 | |
| Hydrochloric Acid SCHEMBL28479231 | 0.84 | F2 (0.49) | F2PRSS1PRSS2PRSS3CA1 | |
| Methylene Chloride SCHEMBL23923198 | 0.79 | F2 (0.45) | F2PRSS1PRSS2PRSS3CA1 | |
| Trifluoroacetic Acid SCHEMBL8316154 | 0.75 | F2 (0.43) | F2PRSS1PRSS2PRSS3CA1 | |
| SCHEMBL20626670 | 0.74 | F2 (0.44) | F2PRSS1PRSS2PRSS3CA1 | |
| SCHEMBL5289461 | 0.71 | ALDH1A1 (0.43) | F2PRSS1PRSS2PRSS3CA1 | |
| SCHEMBL8739532 | 0.70 | F2 (0.41) | F2PRSS1PRSS2PRSS3CA1 | |
| SCHEMBL2678329 | 0.69 | CA1 (0.50) | F2PRSS1PRSS2PRSS3CA1 | |
| SCHEMBL9953282 | 0.68 | F2 (0.50) | F2PRSS1PRSS2PRSS3CA1 | |
| SCHEMBL19309115 | 0.68 | CA2 (0.34) | F2PRSS1PRSS2PRSS3CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2254900-B1 | CHEMICAL MODIFICATION OF PROTEINS | ISIS INNOVATION (GB) | 2012-03-14 | — | — | EP | claimed |