Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 6/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | PRMT6 | Q96LA8 | 7/20 | 0.50 |
| ▸ | PNMT | P11086 | 1/20 | 0.48 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.48 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | NOS3 | P29474 | 4/20 | 0.47 |
| ▸ | NOS2 | P35228 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3363042 | 1.00 | NOS1 (0.53) | NOS1CYP3A4KDM4EMAPTPRMT6 | |
| SCHEMBL22181074 | 0.94 | CYP3A4 (0.61) | NOS1CYP3A4KDM4EMAPTPRMT6 | |
| SCHEMBL8986195 | 0.90 | PRMT6 (0.64) | NOS1CYP3A4KDM4EMAPTPRMT6 | |
| SCHEMBL1697126 | 0.89 | MAPT (0.64) | NOS1CYP3A4KDM4EMAPTPRMT6 | |
| Hydrochloric Acid SCHEMBL3273205 | 0.86 | MAPT (0.68) | NOS1CYP3A4KDM4EMAPTPRMT6 | |
| N-Benzylmethylamine SCHEMBL8215110 | 0.84 | CYP3A4 (0.74) | NOS1CYP3A4KDM4EMAPTPRMT6 | |
| Water SCHEMBL28545356 | 0.83 | LOXL2 (0.67) | NOS1CYP3A4PRMT6PNMTENPP2 | |
| N-Benzylmethylamine SCHEMBL607789 | 0.83 | MAPT (0.78) | NOS1CYP3A4KDM4EMAPTPRMT6 | |
| SCHEMBL30186883 | 0.82 | LOXL2 (0.52) | NOS1CYP3A4PRMT6PNMTENPP2 | |
| SCHEMBL834002 | 0.82 | LOXL2 (0.52) | NOS1CYP3A4PRMT6PNMTENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11530226-B2 | Azepane inhibitors of menin-MLL interaction | JANSSEN PHARMACEUTICA NV (BE) | 2022-12-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11530226-B2 | Azepane inhibitors of menin-MLL interaction | MEN1, MLLT1, BMI1 | NOS1 4550/4885CYP3A4 4491/4885KDM4E 132/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.