Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.59 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.59 |
| ▸ | MAP4K4 | O95819 | 10/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.49 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | TDO2 | P48775 | 1/20 | 0.43 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.42 |
| ▸ | NOS3 | P29474 | 1/20 | 0.42 |
| ▸ | NOS1 | P29475 | 1/20 | 0.42 |
| ▸ | NOS2 | P35228 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL623411 | 0.82 | MAP4K4 (0.61) | MKNK1MKNK2MAP4K4KDM4EALDH1A1 | |
| SCHEMBL1148699 | 0.81 | MAP4K4 (0.66) | MKNK1MKNK2MAP4K4ALDH1A1TDO2 | |
| SCHEMBL4582566 | 0.80 | MKNK1 (0.59) | MKNK1MKNK2MAP4K4NOS3NOS1 | |
| SCHEMBL26071485 | 0.80 | MKNK1 (0.59) | MKNK1MKNK2MAP4K4CYP1A2KDM4E | |
| SCHEMBL2253189 | 0.80 | MKNK1 (0.59) | MKNK1MKNK2MAP4K4CYP1A2KDM4E | |
| SCHEMBL4582572 | 0.80 | MKNK1 (0.59) | MKNK1MKNK2MAP4K4KDM4EALDH1A1 | |
| SCHEMBL624668 | 0.80 | MKNK1 (0.64) | MKNK1MKNK2MAP4K4NOS3NOS1 | |
| SCHEMBL624495 | 0.79 | MKNK1 (0.54) | MKNK1MKNK2MAP4K4KDM4EALDH1A1 | |
| SCHEMBL11127668 | 0.79 | MAP4K4 (0.58) | MKNK1MKNK2MAP4K4TDO2NOS3 | |
| SCHEMBL29442167 | 0.79 | MAP4K4 (0.58) | MKNK1MKNK2MAP4K4TDO2NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12234224-B2 | Pyrimidine and pyridine amine compounds and usage thereof in disease treatment | EPIGEN BIOSCIENCES, INC. (US) | 2025-02-25 | — | — | US | disclosed |
| US-20240124423-A1 | PYRIMIDINE AND PYRIDINE AMINE COMPOUNDS AND USAGE THEREOF IN DISEASE TREATMENT | EPIGEN BIOSCIENCES, INC. (US) | 2024-04-18 | — | — | US | disclosed |
| US-11866421-B2 | Pyrimidine and pyridine amine compounds and usage thereof in disease treatment | EPIGEN BIOSCIENCES, INC. (US) | 2024-01-09 | — | — | US | disclosed |
| US-20220396564-A1 | PYRIMIDINE AND PYRIDINE AMINE COMPOUNDS AND USAGE THEREOF IN DISEASE TREATMENT | EPIGEN BIOSCIENCES, INC. (US) | 2022-12-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12234224-B2 | Pyrimidine and pyridine amine compounds and usage thereof in disease treatment | PDXK, RPS6KA6, RPS6KA4 | MKNK1 113/4885MKNK2 194/4885MAP4K4 119/4885 |
| US-20220396564-A1 | PYRIMIDINE AND PYRIDINE AMINE COMPOUNDS AND USAGE THEREOF IN DISEASE TREATMENT | PDXK, RPS6KA6, RPS6KA4 | MKNK1 113/4885MKNK2 194/4885MAP4K4 119/4885 |
| US-20240124423-A1 | PYRIMIDINE AND PYRIDINE AMINE COMPOUNDS AND USAGE THEREOF IN DISEASE TREATMENT | PDXK, RPS6KA6, RPS6KA4 | MKNK1 113/4885MKNK2 194/4885MAP4K4 119/4885 |
| US-11866421-B2 | Pyrimidine and pyridine amine compounds and usage thereof in disease treatment | PDXK, RPS6KA6, RPS6KA4 | MKNK1 113/4885MKNK2 194/4885MAP4K4 119/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.