Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | PAM | P19021 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | CES1 | P23141 | 2/20 | 0.56 |
| ▸ | CES2 | O00748 | 1/20 | 0.56 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.47 |
| ▸ | FNTA | P49354 | 1/20 | 0.47 |
| ▸ | FNTB | P49356 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL248113 | 0.81 | ALDH1A1 (0.65) | ALDH1A1MAPK1L3MBTL1PAMTSHR | |
| SCHEMBL664857 | 0.81 | ALDH1A1 (0.65) | ALDH1A1MAPK1L3MBTL1PAMTSHR | |
| Benzene SCHEMBL9407299 | 0.81 | ALDH1A1 (0.65) | ALDH1A1MAPK1L3MBTL1PAMTSHR | |
| SCHEMBL247574 | 0.79 | MAPK1 (0.63) | ALDH1A1MAPK1L3MBTL1PAMTSHR | |
| SCHEMBL2877979 | 0.79 | ALDH1A1 (0.63) | ALDH1A1MAPK1L3MBTL1PAMTSHR | |
| SCHEMBL6957861 | 0.78 | L3MBTL1 (0.45) | ALDH1A1MAPK1L3MBTL1SMN1; SMN2KMT2A | |
| SCHEMBL15514077 | 0.78 | POLB (0.53) | ALDH1A1MAPK1L3MBTL1TSHRSMN1; SMN2 | |
| SCHEMBL4642266 | 0.78 | ALDH1A1 (0.57) | ALDH1A1MAPK1L3MBTL1PAMTSHR | |
| SCHEMBL305415 | 0.78 | ALDH1A1 (0.68) | ALDH1A1MAPK1L3MBTL1PAMTSHR | |
| SCHEMBL6964756 | 0.78 | CYP19A1 (0.58) | ALDH1A1CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 945 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9714560-B2 | Protected scale inhibitors and methods relating thereto | HALLIBURTON ENERGY SERVICES, INC. (US) | 2017-07-25 | — | — | US | claimed |
| US-9493469-B2 | Piperidine inhibitors of Janus kinase 3 | AUSPEX PHARMACEUTICALS, INC. (US) | 2016-11-15 | — | — | US | claimed |
| US-20150322094-A1 | USE OF SUBSTITUTED 2,3-DIHYDRO-1-BENZOFURAN-4-CARBOXYLIC ACIDS OR SALTS THEREOF AS ACTIVE SUBSTANCES AGAINST ABIOTIC PLANT STRESS | BAYER CROPSCIENCE AG (DE) | 2015-11-12 | — | — | US | claimed |
| EP-2892343-A1 | USE OF SUBSTITUTED 2,3-DIHYDRO-1-BENZOFURAN-4-CARBOXYLIC ACIDS OR SALTS THEREOF AS ACTIVE SUBSTANCES AGAINST ABIOTIC PLANT STRESS | Bayer CropScience AG (DE) | 2015-07-15 | — | — | EP | claimed |
| US-20140294973-A1 | PHARMACEUTICAL COMPOSITIONS OF HYDROPHOBIC CAMPTOTHECIN DERIVATIVES | TAIWAN LIPOSOME COMPANY, LTD. (TW) | 2014-10-02 | — | — | US | claimed |
| EP-2773346-A1 | PHARMACEUTICAL COMPOSITIONS OF HYDROPHOBIC CAMPTOTHECIN DERIVATIVES | Taiwan Liposome Company, Ltd. (TW) | 2014-09-10 | — | — | EP | claimed |
| US-8779138-B2 | Camptothecin derivatives as chemoradiosensitizing agents | Sutter West Bay Hospital (US) | 2014-07-15 | — | — | US | claimed |
| EP-2727915-A1 | Synthesis of deuterated catechols and benzo[d][1,3]dioxoles and derivatives thereof | Concert Pharmaceuticals Inc. (US) | 2014-05-07 | — | — | EP | claimed |
| WO-2014037349-A1 | USE OF SUBSTITUTED 2,3-DIHYDRO-1-BENZOFURAN-4-CARBOXYLIC ACIDS OR SALTS THEREOF AS ACTIVE SUBSTANCES AGAINST ABIOTIC PLANT STRESS | BAYER CROPSCIENCE AG (DE) | 2014-03-13 | — | — | WO | claimed |
| US-8563537-B2 | Camptothecin derivatives as chemoradiosensitizing agents | Sutter West Bay Hospital (US) | 2013-10-22 | — | — | US | claimed |
| US-5587373-A | ELASTASE INHIBITORS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1996-12-24 | — | — | US | claimed |
| EP-0337704-B1 | Beta-lactam derivatives | PHARMACIA SPA (IT) | 1995-06-14 | — | — | EP | claimed |
| EP-0639195-A1 | 2-ACYLOXYCEPHEM DERIVATIVES AS ELASTASE INHIBITORS | PHARMACIA & UPJOHN S.p.A. (IT) | 1995-02-22 | — | — | EP | claimed |
| WO-1994020504-A1 | 2-ACYLOXYCEPHEM DERIVATIVES AS ELASTASE INHIBITORS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1994-09-15 | — | — | WO | claimed |
| EP-0505413-A1 | BETA-LACTAM DERIVATIVES. | ERBA FARMITALIA (IT) | 1992-09-30 | — | — | EP | claimed |
| US-5077286-A | Human leukocyte elastase inhibitor | FARMITALIA CARLO ERBA S.R.L. (IT) | 1991-12-31 | — | — | US | claimed |
| WO-1991009036-A1 | BETA-LACTAM DERIVATIVES | FARMITALIA CARLO ERBA S.R.L. (IT) | 1991-06-27 | — | — | WO | claimed |
| US-4898939-A | Process for preparing 2β-substituted-methylpenicillin derivatives | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 1990-02-06 | — | — | US | claimed |
| EP-0337229-A2 | Substituted pyri(mi)dines | BAYER AG (DE) | 1989-10-18 | — | — | EP | claimed |
| EP-0337704-A2 | Beta-lactam derivatives | PHARMACIA S.p.A. (IT) | 1989-10-18 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140294973-A1 | PHARMACEUTICAL COMPOSITIONS OF HYDROPHOBIC CAMPTOTHECIN DERIVATIVES | PTEN, LIPA, PHOSPHO1 | ALDH1A1 2697/4885MAPK1 2610/4885L3MBTL1 4747/4885 |
| US-20150322094-A1 | USE OF SUBSTITUTED 2,3-DIHYDRO-1-BENZOFURAN-4-CARBOXYLIC ACIDS OR SALTS THEREOF AS ACTIVE SUBSTANCES AGAINST ABIOTIC PLANT STRESS | CAT, HSF1, HPD | ALDH1A1 24/4885MAPK1 702/4885L3MBTL1 3668/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.