SCHEMBL3013388

SCHEMBL3013388

CC(=O)OCC(OC(C)=O)C(=O)Nc1c(I)c(C(=O)Cl)c(I)c(C(=O)N(C)CC(O)CO)c1I

nearest known ligand 0.50

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.50
CYP2C19 P33261 1/20 0.34
HIF1A Q16665 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3016225 0.91 LMNA (0.40) LMNACYP2C19HIF1A
SCHEMBL3030371 0.89 LMNA (0.49) LMNACYP2C19HIF1A
SCHEMBL10044848 0.87 LMNA (0.61) LMNACYP2C19HIF1A
SCHEMBL13327918 0.87 LMNA (0.47) LMNACYP2C19HIF1A
SCHEMBL10044845 0.87 LMNA (0.55) LMNACYP2C19HIF1A
SCHEMBL4154741 0.86 LMNA (0.53) LMNACYP2C19HIF1A
SCHEMBL13327930 0.86 LMNA (0.46) LMNACYP2C19HIF1A
SCHEMBL3026646 0.85 LMNA (0.36) LMNA
SCHEMBL709410 0.84 LMNA (0.33) LMNA
SCHEMBL3020429 0.83 LMNA (0.46) LMNACYP2C19HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2200971-B1 CONTRAST AGENTS GE HEALTHCARE AS (NO) 2013-04-24 EP disclosed
EP-2200656-B1 CONTRAST AGENTS GE HEALTHCARE AS (NO) 2012-12-05 EP disclosed
US-8323619-B2 Contrast agents GE HEALTHCARE AS (NO) 2012-12-04 US disclosed
US-8323619-B2 Contrast agents GE HEALTHCARE AS (NO) 2012-12-04 US disclosed
US-8323619-B2 Contrast agents GE HEALTHCARE AS (NO) 2012-12-04 US disclosed
EP-2200655-B1 CONTRAST AGENTS GE HEALTHCARE AS (NO) 2012-07-18 EP disclosed
US-8202511-B2 Contrast agents GE HEALTHCARE AS (NO) 2012-06-19 US disclosed
US-8202511-B2 Contrast agents GE HEALTHCARE AS (NO) 2012-06-19 US disclosed
US-8202511-B2 Contrast agents GE HEALTHCARE AS (NO) 2012-06-19 US disclosed
US-20100303734-A1 CONTRAST AGENTS GE HEALTHCARE AS (NO) 2010-12-02 US disclosed
US-20100189656-A1 CONTRAST AGENTS GE HEALTHCARE AS (NO) 2010-07-29 US disclosed
US-20100189656-A1 CONTRAST AGENTS GE HEALTHCARE AS (NO) 2010-07-29 US disclosed
US-20100189656-A1 CONTRAST AGENTS GE HEALTHCARE AS (NO) 2010-07-29 US disclosed
US-20090098059-A1 CONTRAST AGENTS WYNN DUNCAN 2009-04-16 US disclosed
US-20090098059-A1 CONTRAST AGENTS WYNN DUNCAN 2009-04-16 US disclosed
US-20090098059-A1 CONTRAST AGENTS WYNN DUNCAN 2009-04-16 US disclosed
EP-2021317-A1 CONTRAST AGENTS GE Healthcare AS (NO) 2009-02-11 EP disclosed
WO-2009005364-A1 CONTRAST AGENTS GE HEALTHCARE AS (NO) 2009-01-08 WO disclosed
WO-2009005364-A1 CONTRAST AGENTS GE HEALTHCARE AS (NO) 2009-01-08 WO disclosed
WO-2007133090-A1 CONTRAST AGENTS GE HEALTHCARE AS (NO) 2007-11-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090098059-A1 CONTRAST AGENTS IPO4, IPO11, IPO8 LMNA 1824/4885CYP2C19 4562/4885HIF1A 402/4885
US-20100189656-A1 CONTRAST AGENTS IPO4, TPO, IPO11 LMNA 1835/4885CYP2C19 4234/4885HIF1A 1213/4885
US-20100303734-A1 CONTRAST AGENTS C1R, CNKSR1, C5 LMNA 2025/4885CYP2C19 2823/4885HIF1A 345/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.