Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 5/20 | 0.42 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.41 |
| ▸ | WNT3A | P56704 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.40 |
| ▸ | NOS1 | P29475 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16023025 | 0.79 | RAB9A (0.50) | ROCK2MAOBRAB9ANPC1ROCK1 | |
| SCHEMBL5417396 | 0.78 | ESR1 (0.44) | ROCK2MAOBRAB9ANPC1ROCK1 | |
| SCHEMBL5408031 | 0.78 | MEN1 (0.42) | ROCK2MAOBRAB9ANPC1ROCK1 | |
| SCHEMBL28707122 | 0.77 | NOS1 (0.46) | ROCK2CTNNB1WNT3AMAOBRAB9A | |
| SCHEMBL23622136 | 0.77 | NR3C1 (0.47) | ROCK2 | |
| SCHEMBL14738568 | 0.76 | MAPT (0.52) | ROCK2CTNNB1WNT3AMAOBRAB9A | |
| SCHEMBL30540770 | 0.76 | KDR (0.56) | NOS1FGFR1FGFR2 | |
| SCHEMBL30498934 | 0.76 | KDR (0.56) | NOS1FGFR1FGFR2 | |
| SCHEMBL1336326 | 0.75 | JAK2 (0.41) | ROCK2ROCK1CSNK2A1FGFR1FGFR2 | |
| SCHEMBL23622250 | 0.74 | NR3C1 (0.57) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022268080-A1 | TRK KINASE INHIBITOR COMPOUND AND USE THEREOF | 河南迈英诺医药科技有限公司 | 2022-12-29 | — | — | WO | disclosed |