SCHEMBL30145458

SCHEMBL30145458

C[C@H](CNC[C@H](O)Cn1c2ccccc2c2ccccc21)NC(=O)OC(C)(C)C

nearest known ligand 0.53

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ DNM1 Q05193 17/20 0.52
▸ MITF O75030 1/20 0.49
▸ ALDH1A1 P00352 1/20 0.49
▸ LMNA P02545 1/20 0.49
▸ SMN1; SMN2 Q16637 1/20 0.49
▸ NPSR1 Q6W5P4 1/20 0.49
▸ PER2 O15055 1/20 0.49
▸ CRY1 Q16526 1/20 0.49
▸ CRY2 Q49AN0 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28701935 1.00 DNM1 (0.52) DNM1MITFALDH1A1LMNASMN1; SMN2
SCHEMBL29558821 1.00 DNM1 (0.52) DNM1MITFALDH1A1LMNASMN1; SMN2
SCHEMBL30145482 1.00 DNM1 (0.52) DNM1MITFALDH1A1LMNASMN1; SMN2
SCHEMBL29558281 1.00 DNM1 (0.52) DNM1MITFALDH1A1LMNASMN1; SMN2
SCHEMBL17147695 1.00 DNM1 (0.52) DNM1MITFALDH1A1LMNASMN1; SMN2
SCHEMBL17147693 1.00 DNM1 (0.52) DNM1MITFALDH1A1LMNASMN1; SMN2
SCHEMBL17147690 0.85 PER2 (0.53) PER2CRY1CRY2
SCHEMBL17147692 0.85 PER2 (0.53) PER2CRY1CRY2
SCHEMBL17147694 0.85 PER2 (0.53) PER2CRY1CRY2
SCHEMBL29558339 0.85 PER2 (0.53) PER2CRY1CRY2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240190837-A1 CARBAZOLE-CONTAINING AMIDES, CARBAMATES, AND UREAS AS CRYPTOCHROME MODULATORS SYCHRONICITY PHARMA INC (US) 2024-06-13 — — US disclosed
US-20220411399-A1 CARBAZOLE-CONTAINING AMIDES, CARBAMATES, AND UREAS AS CRYPTOCHROME MODULATORS SYCHRONICITY PHARMA INC (US) 2022-12-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220411399-A1 CARBAZOLE-CONTAINING AMIDES, CARBAMATES, AND UREAS AS CRYPTOCHROME MODULATORS CRY1, CRY2, HCCS DNM1 2945/4885MITF 1789/4885ALDH1A1 2882/4885
US-20240190837-A1 CARBAZOLE-CONTAINING AMIDES, CARBAMATES, AND UREAS AS CRYPTOCHROME MODULATORS CRY1, CRY2, HCCS DNM1 2945/4885MITF 1789/4885ALDH1A1 2882/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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