Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 1/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 9/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.42 |
| ▸ | RXRA | P19793 | 2/20 | 0.40 |
| ▸ | RXRB | P28702 | 1/20 | 0.40 |
| ▸ | RXRG | P48443 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RARB | P10826 | 1/20 | 0.39 |
| ▸ | RARG | P13631 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3024103 | 0.87 | PGR (0.46) | PGRPIK3CDEPHX2ALOX5 | |
| SCHEMBL13735589 | 0.81 | PGR (0.65) | PGRPIK3CDEPHX2PIK3R1 | |
| SCHEMBL7834463 | 0.79 | PGR (0.59) | PGRPIK3CDEPHX2PIK3R1SMN1; SMN2 | |
| SCHEMBL3839942 | 0.76 | MAPK14 (0.57) | PGRRXRARXRBRXRGALOX5 | |
| SCHEMBL29906734 | 0.76 | MAPK14 (0.57) | PGRRXRARXRBRXRGALOX5 | |
| SCHEMBL9773675 | 0.73 | POLB (0.44) | PGRALOX5SMN1; SMN2HTTRARB | |
| SCHEMBL19410676 | 0.72 | PGR (0.62) | PGRPIK3CDEPHX2PIK3R1 | |
| SCHEMBL9773670 | 0.69 | HRH3 (0.40) | RXRARXRBRXRGSMN1; SMN2RARB | |
| SCHEMBL9773677 | 0.69 | IP6K1 (0.52) | RXRAHTT | |
| SCHEMBL9773679 | 0.69 | ALDH1A1 (0.44) | RXRARXRBRXRGALOX5SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9394267-B2 | Heterocyclic modulators of cannabinoid receptors | THE CLEVELAND CLINIC FOUNDATION (US) | 2016-07-19 | — | — | US | disclosed |
| US-9339486-B2 | Heterocyclic modulators of cannabinoid receptors | THE CLEVELAND CLINIC FOUNDATION (US) | 2016-05-17 | — | — | US | disclosed |
| US-20150148408-A1 | HETEROCYCLIC MODULATORS OF CANNABINOID RECEPTORS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2015-05-28 | — | — | US | disclosed |
| CN-101801187-B | Heterocyclic modulators of cannabinoid receptors | UNIV TEXAS | 2014-07-23 | — | — | CN | disclosed |
| EP-2178371-B1 | HETEROCYCLIC MODULATORS OF CANNABINOID RECEPTORS | UNIV TEXAS (US) | 2014-01-01 | — | — | EP | disclosed |
| US-20130237536-A1 | HETEROCYCLIC MODULATORS OF CANNABINOID RECEPTORS | THE CLEVELAND CLINIC FOUNDATION (US) | 2013-09-12 | — | — | US | disclosed |
| US-8440832-B2 | Heterocyclic modulators of cannabinoid receptors | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2013-05-14 | — | — | US | disclosed |
| US-20100204220-A1 | HETEROCYCLIC MODULATORS OF CANNABINOID RECEPTORS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2010-08-12 | — | — | US | disclosed |
| CN-101801187-A | heterocyclic modulators of cannabinoid receptors | UNIV TEXAS | 2010-08-11 | — | — | CN | disclosed |
| EP-2178371-A1 | HETEROCYCLIC MODULATORS OF CANNABINOID RECEPTORS | Board of Regents, The University of Texas System (US) | 2010-04-28 | — | — | EP | disclosed |
| WO-2009012221-A1 | HETEROCYCLIC MODULATORS OF CANNABINOID RECEPTORS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2009-01-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100204220-A1 | HETEROCYCLIC MODULATORS OF CANNABINOID RECEPTORS | CNR1, CNR2, GPR18 | PGR 712/4885PIK3CD 508/4885EPHX2 835/4885 |
| US-20130237536-A1 | HETEROCYCLIC MODULATORS OF CANNABINOID RECEPTORS | CNR1, CNR2, GPR18 | PGR 712/4885PIK3CD 508/4885EPHX2 835/4885 |
| US-20150148408-A1 | HETEROCYCLIC MODULATORS OF CANNABINOID RECEPTORS | CNR1, CNR2, GPR18 | PGR 712/4885PIK3CD 508/4885EPHX2 835/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.