Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 1/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3014576 | 0.87 | PGR (0.50) | PGRPIK3CDALOX5EPHX2 | |
| SCHEMBL16321516 | 0.77 | MAPK14 (0.53) | PGRALOX5LMNAALDH1A1PDK2 | |
| SCHEMBL29825095 | 0.77 | MAPK14 (0.53) | PGRALOX5LMNAALDH1A1PDK2 | |
| SCHEMBL13735589 | 0.77 | PGR (0.65) | PGRPIK3CDEPHX2 | |
| SCHEMBL7834463 | 0.75 | PGR (0.59) | PGRPIK3CDLMNAALDH1A1EPHX2 | |
| SCHEMBL24885552 | 0.73 | ALDH1A1 (0.48) | ALOX5LMNAALDH1A1PDK2CA1 | |
| SCHEMBL31411757 | 0.72 | MAPK14 (0.50) | ALOX5LMNAALDH1A1 | |
| SCHEMBL19693406 | 0.72 | LMNA (0.49) | ALOX5LMNAALDH1A1PDK2CA1 | |
| SCHEMBL28038157 | 0.71 | LNPEP (0.40) | ALOX5LMNAALDH1A1PDK2CA1 | |
| SCHEMBL3021003 | 0.70 | CNR2 (0.66) | ALOX5LMNAALDH1A1PDK2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9394267-B2 | Heterocyclic modulators of cannabinoid receptors | THE CLEVELAND CLINIC FOUNDATION (US) | 2016-07-19 | — | — | US | disclosed |
| US-9339486-B2 | Heterocyclic modulators of cannabinoid receptors | THE CLEVELAND CLINIC FOUNDATION (US) | 2016-05-17 | — | — | US | disclosed |
| US-20150148408-A1 | HETEROCYCLIC MODULATORS OF CANNABINOID RECEPTORS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2015-05-28 | — | — | US | disclosed |
| EP-2178371-B1 | HETEROCYCLIC MODULATORS OF CANNABINOID RECEPTORS | UNIV TEXAS (US) | 2014-01-01 | — | — | EP | disclosed |
| US-20130237536-A1 | HETEROCYCLIC MODULATORS OF CANNABINOID RECEPTORS | THE CLEVELAND CLINIC FOUNDATION (US) | 2013-09-12 | — | — | US | disclosed |
| US-8440832-B2 | Heterocyclic modulators of cannabinoid receptors | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2013-05-14 | — | — | US | disclosed |
| US-20100204220-A1 | HETEROCYCLIC MODULATORS OF CANNABINOID RECEPTORS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2010-08-12 | — | — | US | disclosed |
| EP-2178371-A1 | HETEROCYCLIC MODULATORS OF CANNABINOID RECEPTORS | Board of Regents, The University of Texas System (US) | 2010-04-28 | — | — | EP | disclosed |
| WO-2009012221-A1 | HETEROCYCLIC MODULATORS OF CANNABINOID RECEPTORS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2009-01-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100204220-A1 | HETEROCYCLIC MODULATORS OF CANNABINOID RECEPTORS | CNR1, CNR2, GPR18 | PGR 712/4885PIK3CD 508/4885ALOX5 812/4885 |
| US-20130237536-A1 | HETEROCYCLIC MODULATORS OF CANNABINOID RECEPTORS | CNR1, CNR2, GPR18 | PGR 712/4885PIK3CD 508/4885ALOX5 812/4885 |
| US-20150148408-A1 | HETEROCYCLIC MODULATORS OF CANNABINOID RECEPTORS | CNR1, CNR2, GPR18 | PGR 712/4885PIK3CD 508/4885ALOX5 812/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.