Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 7/20 | 0.43 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | NAMPT | P43490 | 2/20 | 0.34 |
| ▸ | BRD4 | O60885 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | ALPL | P05186 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22637868 | 0.81 | ALKBH1 (0.36) | ALDH1A1MAPTPOLB | |
| SCHEMBL8568083 | 0.75 | GAA (0.69) | GAABAZ2BATMALDH1A1CYP1A2 | |
| SCHEMBL20028548 | 0.74 | TSHR (0.43) | BAZ2BALDH1A1RAB9ANPC1MAPT | |
| SCHEMBL17741451 | 0.72 | BACE1 (0.42) | RAB9A | |
| SCHEMBL22979652 | 0.70 | P2RX7 (0.42) | GAAATMALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL23928418 | 0.69 | LMNA (0.37) | GAAATMALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL13975783 | 0.68 | BAZ2B (0.45) | BAZ2BBRD4 | |
| SCHEMBL30147529 | 0.67 | PLK1 (0.43) | SMN1; SMN2 | |
| SCHEMBL30147538 | 0.67 | PLK1 (0.49) | SMN1; SMN2 | |
| SCHEMBL12092481 | 0.67 | GAA (0.43) | GAABAZ2BALDH1A1CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023192901-A9 | QUINOLINE DERIVATIVES AS MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS | ESCIENT PHARMACEUTICALS, INC. (US) | 2023-12-14 | — | — | WO | disclosed |
| WO-2023192901-A1 | QUINOLINE DERIVATIVES AS MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS | ESCIENT PHARMACEUTICALS, INC. (US) | 2023-10-05 | — | — | WO | disclosed |