Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.44 |
| ▸ | FOS | P01100 | 1/20 | 0.42 |
| ▸ | TTR | P02766 | 1/20 | 0.42 |
| ▸ | JUN | P05412 | 1/20 | 0.42 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.42 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.42 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2739018 | 0.86 | HTR2A (0.68) | HTR2A | |
| SCHEMBL5469292 | 0.83 | HTR2A (0.44) | HTR2AMAOBALOX15ALOX12 | |
| SCHEMBL5882359 | 0.82 | L3MBTL1 (0.42) | GAAGABRA1GABRB2KDM4EMEN1 | |
| SCHEMBL27453036 | 0.79 | ACHE (0.52) | HTR2AGAAALDH1A1 | |
| SCHEMBL10148127 | 0.79 | HTR2A (0.50) | HTR2AGAAKDM4EMEN1ALDH1A1 | |
| SCHEMBL4960829 | 0.79 | HTR2A (0.74) | HTR2AGAAHSD17B10 | |
| SCHEMBL14551457 | 0.79 | ALOX15 (0.47) | HTR2AALOX15ALOX12GAAGABRA1 | |
| SCHEMBL16625523 | 0.79 | MAOB (0.52) | MAOBALOX15GAATTRKDM4E | |
| SCHEMBL29392084 | 0.79 | MAOB (0.52) | MAOBALOX15GAATTRKDM4E | |
| SCHEMBL178369 | 0.79 | MAOB (0.52) | MAOBALOX15GAATTRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022221774-A1 | ARYL-RING-SUBSTITUTED 3-PHENYLAZETIDINES AND THEIR USE IN METHODS FOR TREATING 5-HT2 RESPONSIVE CONDITIONS | ELEUSIS THERAPEUTICS US, INC. (US) | 2022-10-20 | — | — | WO | disclosed |