SCHEMBL30148717

SCHEMBL30148717

CNC(=O)Oc1cnc(OC)c(N2CCN(C)C2=O)c1

nearest known ligand 0.34

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.34
ACHE P22303 12/20 0.34
BCHE P06276 6/20 0.34
KDM4E B2RXH2 5/20 0.33
CYP2D6 P10635 2/20 0.33
MEN1 O00255 1/20 0.33
CYP1A2 P05177 1/20 0.33
KMT2A Q03164 1/20 0.33
HIF1A Q16665 1/20 0.33
LMNA P02545 1/20 0.33
PTGS1 P23219 1/20 0.33
OPRM1 P35372 1/20 0.33
OPRK1 P41145 1/20 0.33
BLM P54132 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
HRH3 Q9Y5N1 1/20 0.33
PIK3CD O00329 2/20 0.32
HSD17B10 Q99714 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29180832 0.86 CYP11B2 (0.35) HRH3
SCHEMBL30148659 0.78 PARP1 (0.32) PIK3CD
Hydrochloric Acid SCHEMBL29180786 0.77 CYP17A1 (0.33)
SCHEMBL30148626 0.77 RAF1 (0.38)
SCHEMBL24804886 0.76 SCN9A (0.35) HRH3PIK3CD
SCHEMBL30772165 0.76 SCN9A (0.35) HRH3PIK3CD
SCHEMBL24802440 0.76 CYP17A1 (0.37) HRH3PIK3CD
SCHEMBL29180862 0.75 RORC (0.42) ACHE
SCHEMBL30772208 0.75 RORC (0.42) ACHE
SCHEMBL30772189 0.71 KAT2B (0.37) ALDH1A1MEN1KMT2ALMNAOPRK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022268209-A1 DERIVATIVE HAVING PYRIMIDINE-FUSED CYCLIC STRUCTURE, AND USE THEREOF 四川汇宇制药股份有限公司 2022-12-29 WO disclosed