SCHEMBL30148840

SCHEMBL30148840

O=C(O)CN1CCC2(CCOC2)C1

nearest known ligand 0.46

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 1/20 0.46
MCHR1 Q99705 3/20 0.37
HDAC6 Q9UBN7 1/20 0.36
ITGB3 P05106 4/20 0.36
ITGA2B P08514 4/20 0.36
GLA P06280 1/20 0.33
TLR9 Q9NR96 1/20 0.32
TLR8 Q9NR97 1/20 0.32
TLR7 Q9NYK1 1/20 0.32
GRM2 Q14416 1/20 0.31
RORC P51449 1/20 0.31
KCNH2 Q12809 1/20 0.31
KDM4E B2RXH2 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28515095 0.88 HSD17B10 (0.46) HSD17B10MCHR1HDAC6ITGB3ITGA2B
SCHEMBL28528221 0.80 HSD17B10 (0.53) HSD17B10ITGB3ITGA2BGLAKDM4E
SCHEMBL28511047 0.80 HSD17B10 (0.53) HSD17B10HDAC6ITGB3ITGA2BGLA
SCHEMBL14671193 0.80 ITGB3 (0.42) HSD17B10ITGB3ITGA2B
SCHEMBL30148862 0.79 TSHR (0.38) MCHR1HDAC6TLR9TLR8TLR7
SCHEMBL14671149 0.77 ITGB3 (0.43) HSD17B10ITGB3ITGA2B
SCHEMBL31270210 0.76 L3MBTL1 (0.42) MCHR1HDAC6ITGB3ITGA2BGLA
SCHEMBL28518764 0.76 HSD17B10 (0.47) HSD17B10ITGB3ITGA2BGLA
SCHEMBL12312347 0.75 TSHR (0.47) MCHR1HDAC6RORCKCNH2KDM4E
SCHEMBL21620152 0.75 HDAC6 (0.32) MCHR1HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115521325-A Boronic acid derivatives 首药控股(北京)股份有限公司 2022-12-27 CN disclosed