Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 2/20 | 0.50 |
| ▸ | THRB | P10828 | 2/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 8/20 | 0.49 |
| ▸ | FFAR4 | Q5NUL3 | 4/20 | 0.47 |
| ▸ | RXRA | P19793 | 2/20 | 0.44 |
| ▸ | RXRB | P28702 | 2/20 | 0.44 |
| ▸ | RXRG | P48443 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.42 |
| ▸ | HSPH1 | Q92598 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1015795 | 0.88 | LMNA (0.54) | THRATHRBFFAR1FFAR4RXRA | |
| Trifluoroacetic Acid SCHEMBL30151192 | 0.83 | THRA (0.40) | THRATHRBFFAR1FFAR4LMNA | |
| SCHEMBL10153376 | 0.83 | RXRA (0.54) | THRBFFAR4RXRARXRBRXRG | |
| SCHEMBL1249170 | 0.82 | KEAP1 (0.52) | THRATHRBFFAR1FFAR4RXRA | |
| SCHEMBL17310946 | 0.81 | RXRA (0.51) | THRATHRBFFAR1FFAR4RXRA | |
| SCHEMBL30151135 | 0.80 | THRA (0.47) | THRATHRBFFAR1FFAR4RXRA | |
| SCHEMBL30151169 | 0.80 | FFAR4 (0.48) | THRATHRBFFAR1FFAR4RXRA | |
| SCHEMBL7812479 | 0.77 | LMNA (0.51) | THRATHRBFFAR1FFAR4RXRA | |
| SCHEMBL3930469 | 0.77 | FFAR4 (0.47) | THRATHRBFFAR1FFAR4RXRA | |
| SCHEMBL18255658 | 0.76 | FFAR1 (0.50) | THRATHRBFFAR1FFAR4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115551846-B | 1,4,5, 6-tetrahydropyrimidin-2-amine derivatives | ＵＢＥ株式会社 | 2024-03-08 | — | — | CN | claimed |
| WO-2023085396-A1 | PHARMACEUTICAL COMPOSITION FOR PROVIDING TREATMENT FOR OR PREVENTING ALPORT SYNDROME | ＵＢＥ株式会社 | 2023-05-19 | — | — | WO | claimed |
| CN-115551846-A | 1,4,5,6-tetrahydropyrimidin-2-amine derivatives | ＵＢＥ株式会社 | 2022-12-30 | — | — | CN | claimed |
| CN-115551846-B | 1,4,5, 6-tetrahydropyrimidin-2-amine derivatives | ＵＢＥ株式会社 | 2024-03-08 | — | — | CN | disclosed |
| WO-2023085396-A1 | PHARMACEUTICAL COMPOSITION FOR PROVIDING TREATMENT FOR OR PREVENTING ALPORT SYNDROME | ＵＢＥ株式会社 | 2023-05-19 | — | — | WO | disclosed |
| CN-115551846-A | 1,4,5,6-tetrahydropyrimidin-2-amine derivatives | ＵＢＥ株式会社 | 2022-12-30 | — | — | CN | disclosed |