Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 11/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | RAD52 | P43351 | 1/20 | 0.34 |
| ▸ | FABP4 | P15090 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24928850 | 1.00 | ACLY (0.36) | ACLYL3MBTL1PTK2BSMN1; SMN2POLB | |
| SCHEMBL31198500 | 0.91 | ACLY (0.38) | ACLYL3MBTL1PTK2BSMN1; SMN2POLB | |
| SCHEMBL30153324 | 0.91 | ACLY (0.38) | ACLYL3MBTL1PTK2BSMN1; SMN2POLB | |
| SCHEMBL24928651 | 0.91 | ACLY (0.38) | ACLYL3MBTL1PTK2BSMN1; SMN2POLB | |
| SCHEMBL24928843 | 0.91 | ACLY (0.38) | ACLYL3MBTL1PTK2BSMN1; SMN2POLB | |
| SCHEMBL24928948 | 0.86 | NR1H4 (0.30) | — | |
| SCHEMBL30845553 | 0.85 | ACLY (0.40) | ACLYL3MBTL1SMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL30153260 | 0.85 | ACLY (0.40) | ACLYL3MBTL1SMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL31198427 | 0.83 | ACLY (0.41) | ACLYPTK2BSMN1; SMN2RAD52FABP4 | |
| SCHEMBL24928655 | 0.83 | ACLY (0.41) | ACLYPTK2BSMN1; SMN2RAD52FABP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4376955-A1 | PHENYL-SULFAMOYL-BENZOIC ACID DERIVATIVES AS ERAP1- MODULATORS | Grey Wolf Therapeutics Limited (GB) | 2024-06-05 | — | — | EP | disclosed |
| CN-117881657-A | Phenyl-sulfamoyl-benzoic acid derivatives as ERAP1 modulators | 格雷沃尔夫治疗有限公司 | 2024-04-12 | — | — | CN | disclosed |
| WO-2023007188-A1 | PHENYL-SULFAMOYL-BENZOIC ACID DERIVATIVES AS ERAP1- MODULATORS | Grey Wolf Therapeutics Limited (GB) | 2023-02-02 | — | — | WO | disclosed |