Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | CTSS | P25774 | 8/20 | 0.34 |
| ▸ | CTSK | P43235 | 8/20 | 0.34 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA7 | P43166 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CTSL | P07711 | 2/20 | 0.33 |
| ▸ | CTSB | P07858 | 2/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.32 |
| ▸ | AKT1 | P31749 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14282687 | 0.82 | CTSK (0.41) | MEN1GAAKMT2ACTSSCTSK | |
| SCHEMBL25874746 | 0.81 | CTSK (0.32) | MEN1GAAKMT2ACTSSCTSK | |
| SCHEMBL29957057 | 0.76 | CTSK (0.37) | MEN1GAAKMT2ACTSSCTSK | |
| SCHEMBL6292986 | 0.75 | TDP1 (0.37) | MEN1GAAKMT2ACTSSCTSK | |
| SCHEMBL2187338 | 0.74 | NPC1 (0.36) | MEN1GAAKMT2ACTSSCTSK | |
| SCHEMBL2911305 | 0.74 | CTSS (0.40) | MEN1KMT2ACTSSCTSKTDP1 | |
| SCHEMBL132657 | 0.69 | DGAT1 (0.42) | MEN1GAAKMT2ACTSKCA1 | |
| SCHEMBL21410149 | 0.69 | PTPN11 (0.49) | MEN1GAAKMT2ACTSSCTSK | |
| SCHEMBL25229366 | 0.69 | MEN1 (0.44) | MEN1GAAKMT2ACTSSCTSK | |
| SCHEMBL76832 | 0.69 | KDM4C (0.41) | MEN1GAAKMT2ACTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4373825-A1 | NITRILE SUMO INHIBITORS AND USES THEREOF | Suvalent Therapeutics, Inc. (US) | 2024-05-29 | — | — | EP | disclosed |
| WO-2023004376-A1 | NITRILE SUMO INHIBITORS AND USES THEREOF | Suvalent Therapeutics, Inc. (US) | 2023-01-26 | — | — | WO | disclosed |