SCHEMBL30155752

SCHEMBL30155752

CC(=O)N1CCC[C@H](Nc2cccc3c2CN(C(=O)c2c(O)cc(O)cc2OCc2ccccc2)CC3)C1

nearest known ligand 0.37

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
TMEM97 Q5BJF2 2/20 0.36
SIGMAR1 Q99720 2/20 0.36
L3MBTL1 Q9Y468 1/20 0.35
MEN1 O00255 1/20 0.35
ALDH1A1 P00352 1/20 0.35
LMNA P02545 1/20 0.35
MAPT P10636 1/20 0.35
HPGD P15428 1/20 0.35
KMT2A Q03164 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
PTGDR2 Q9Y5Y4 3/20 0.35
MAPK3 P27361 3/20 0.35
GAA P10253 2/20 0.35
POLB P06746 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30155749 1.00 TMEM97 (0.36) TMEM97SIGMAR1L3MBTL1MEN1ALDH1A1
SCHEMBL30155831 0.95 SPR (0.38) TMEM97SIGMAR1L3MBTL1PTGDR2
SCHEMBL24913993 0.95 SPR (0.38) TMEM97SIGMAR1L3MBTL1PTGDR2
SCHEMBL24913991 0.95 SPR (0.38) TMEM97SIGMAR1L3MBTL1PTGDR2
SCHEMBL30155795 0.95 SPR (0.38) TMEM97SIGMAR1L3MBTL1PTGDR2
SCHEMBL24913891 0.93 TMEM97 (0.38) TMEM97SIGMAR1L3MBTL1ALDH1A1MAPT
SCHEMBL30155743 0.93 TMEM97 (0.38) TMEM97SIGMAR1L3MBTL1ALDH1A1MAPT
SCHEMBL24914229 0.91 NSD2 (0.40) TMEM97SIGMAR1ALDH1A1MAPTPTGDR2
SCHEMBL30155850 0.91 NSD2 (0.40) TMEM97SIGMAR1ALDH1A1MAPTPTGDR2
SCHEMBL24913940 0.91 TMEM97 (0.42) TMEM97SIGMAR1L3MBTL1MEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117693507-A Inhibitor compounds 奈奥芬莱有限公司 2024-03-12 CN claimed
WO-2023002165-A1 INHIBITOR COMPOUNDS Neophore Limited (GB) 2023-01-26 WO claimed
US-20240293392-A1 INHIBITOR COMPOUNDS Neophore Limited (GB) 2024-09-05 US disclosed
CN-117693507-A Inhibitor compounds 奈奥芬莱有限公司 2024-03-12 CN disclosed
WO-2023002165-A1 INHIBITOR COMPOUNDS Neophore Limited (GB) 2023-01-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240293392-A1 INHIBITOR COMPOUNDS MSH2, PMS2, MSH6 TMEM97 3224/4885SIGMAR1 4779/4885L3MBTL1 1833/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.