Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C4 | P17516 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.44 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | ACLY | P53396 | 5/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | TPMT | P51580 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23529330 | 1.00 | AKR1C4 (0.44) | AKR1C4AKR1C3AKR1C2AKR1C1CYP3A4 | |
| SCHEMBL23529377 | 0.81 | ERN1 (0.47) | AKR1C2AKR1C1CYP3A4KEAP1NFE2L2 | |
| SCHEMBL29948173 | 0.81 | ERN1 (0.47) | AKR1C2AKR1C1CYP3A4KEAP1NFE2L2 | |
| SCHEMBL906303 | 0.81 | AKR1C4 (0.57) | AKR1C4AKR1C3AKR1C2AKR1C1CYP3A4 | |
| SCHEMBL1349783 | 0.80 | ERN1 (0.41) | CYP3A4ALDH1A1HSD17B10TSHRGRM2 | |
| SCHEMBL11179328 | 0.75 | ERN1 (0.43) | CYP3A4ALDH1A1HPGDHSD17B10CA1 | |
| SCHEMBL23529333 | 0.75 | ALDH1A1 (0.48) | AKR1C4AKR1C3AKR1C2AKR1C1CYP3A4 | |
| SCHEMBL6242355 | 0.75 | AKR1C2 (0.64) | AKR1C4AKR1C3AKR1C2AKR1C1CYP3A4 | |
| SCHEMBL25296415 | 0.74 | TSHR (0.41) | CYP3A4KEAP1NFE2L2ALDH1A1TP53 | |
| SCHEMBL5357933 | 0.74 | KEAP1 (0.46) | AKR1C4AKR1C3AKR1C2AKR1C1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022266711-A1 | SUBSTITUTED AMIDOBENZIMIDAZOLE DIMERS AS STING MODULATORS | Aculeus Therapeutics Pty Ltd (AU) | 2022-12-29 | — | — | WO | disclosed |