Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ASPH | Q12797 | 1/20 | 0.34 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | KDM4A | O75164 | 1/20 | 0.33 |
| ▸ | KDM5A | P29375 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14408184 | 0.81 | KEAP1 (0.42) | KEAP1NFE2L2CYP3A4KDM4EASPH | |
| SCHEMBL14408166 | 0.81 | KEAP1 (0.42) | KEAP1NFE2L2CYP3A4KDM4EASPH | |
| SCHEMBL14408181 | 0.81 | KEAP1 (0.42) | KEAP1NFE2L2CYP3A4KDM4EASPH | |
| SCHEMBL19688093 | 0.80 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2CA1CA2CA12 | |
| SCHEMBL8974977 | 0.78 | KEAP1 (0.53) | KEAP1NFE2L2CYP3A4KDM4EASPH | |
| SCHEMBL25296415 | 0.78 | TSHR (0.41) | KEAP1NFE2L2CYP3A4TSHRALDH1A1 | |
| SCHEMBL30159547 | 0.74 | AKR1C4 (0.44) | KEAP1NFE2L2CYP3A4DYRK1ATSHR | |
| SCHEMBL23529330 | 0.74 | AKR1C4 (0.44) | KEAP1NFE2L2CYP3A4DYRK1ATSHR | |
| SCHEMBL7041352 | 0.73 | CYP3A4 (0.50) | KEAP1NFE2L2CYP3A4KDM4EASPH | |
| SCHEMBL7596205 | 0.73 | KEAP1 (0.48) | KEAP1NFE2L2CYP3A4KDM4EASPH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7268248-B2 | Bichlorinated compounds formed under with carboxy groupand elimation of water | BAYER AKTIENGESELLSCHAFT (DE) | 2007-09-11 | — | — | US | claimed |
| US-20040167350-A1 | Bichlorinated compounds formed under with carboxy groupand elimation of water | MARHOLD ALBRECHT (DE) | 2004-08-26 | — | — | US | claimed |
| US-6706918-B2 | USING HALOGENATED XYLENE COMPOUND; CHEMICAL INTERMEDIATE FOR QUINOLONE ANTIBIOTICS | BAYER AKTIENGESELLSCHAFT (DE) | 2004-03-16 | — | — | US | claimed |
| US-20030092929-A1 | Using halogenated xylene compound; chemical intermediate for quinolone antibiotics | MARHOLD ALBRECHT (DE) | 2003-05-15 | — | — | US | claimed |
| EP-0977729-B1 | 3-CYANO-2,4,5-TRIFLUORO-BENZOYL FLUORIDE AND INTERMEDIATE PRODUCTS FOR THE PRODUCTION THEREOF | BAYER AG (DE) | 2002-03-13 | — | — | EP | claimed |
| US-20010023300-A1 | Preparing by reacting 3-cyano-2,4-dichloro-4-fluoro-benzoyl chloride nucleophilically with a fluoridizing agent; forming 3-cyano-2,4,5-trifluoro-benzoyl chloride from title compound; intermediates to antiinfective quinolonecarboxylic acids | MARHOLD ALBRECHT (DE) | 2001-09-20 | — | — | US | claimed |
| EP-0977729-A1 | 3-CYANO-2,4,5-TRIFLUORO-BENZOYL FLUORIDE AND INTERMEDIATE PRODUCTS FOR THE PRODUCTION THEREOF | BAYER AG (DE) | 2000-02-09 | — | — | EP | claimed |
| WO-1998047862-A1 | 3-CYANO-2,4,5-TRIFLUORO-BENZOYL FLUORIDE AND INTERMEDIATE PRODUCTS FOR THE PRODUCTION THEREOF | BAYER AKTIENGESELLSCHAFT (DE) | 1998-10-29 | — | — | WO | claimed |
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |
| US-7268248-B2 | Bichlorinated compounds formed under with carboxy groupand elimation of water | BAYER AKTIENGESELLSCHAFT (DE) | 2007-09-11 | — | — | US | disclosed |
| US-7268248-B2 | Bichlorinated compounds formed under with carboxy groupand elimation of water | BAYER AKTIENGESELLSCHAFT (DE) | 2007-09-11 | — | — | US | disclosed |
| US-7268248-B2 | Bichlorinated compounds formed under with carboxy groupand elimation of water | BAYER AKTIENGESELLSCHAFT (DE) | 2007-09-11 | — | — | US | disclosed |
| US-20040167350-A1 | Bichlorinated compounds formed under with carboxy groupand elimation of water | MARHOLD ALBRECHT (DE) | 2004-08-26 | — | — | US | disclosed |
| US-6706918-B2 | USING HALOGENATED XYLENE COMPOUND; CHEMICAL INTERMEDIATE FOR QUINOLONE ANTIBIOTICS | BAYER AKTIENGESELLSCHAFT (DE) | 2004-03-16 | — | — | US | disclosed |
| EP-0977729-A1 | 3-CYANO-2,4,5-TRIFLUORO-BENZOYL FLUORIDE AND INTERMEDIATE PRODUCTS FOR THE PRODUCTION THEREOF | BAYER AG (DE) | 2000-02-09 | — | — | EP | disclosed |
| EP-0946176-A1 | THE USE OF 7-(2-OXA-5,8-DIAZABICYCLO 4.3.0]NON-8-YL)-QUINOLONE CARBOXYLIC ACID AND NAPHTHYRIDON CARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT OF HELICOBACTER PYLORI INFECTIONS AND ASSOCIATED GASTRODUODENAL DISEASES | BAYER AG (DE) | 1999-10-06 | — | — | EP | disclosed |
| EP-0944385-A2 | USE OF 7-(1-AMINOMETHYL-2-OXA-7-AZA-BICYCLO 3.3.0]OCT-7-YL)-QUINOLONE CARBOXYLIC ACID AND NAPHTHYRIDONE CARBOXYLIC ACID DERIVATIVES FOR TREATING $i(HELICOBACTER PYLORI) INFECTIONS AND THE GASTRODUODENAL DISEASES ASSOCIATED THEREWITH | BAYER AG (DE) | 1999-09-29 | — | — | EP | disclosed |
| WO-1998047862-A1 | 3-CYANO-2,4,5-TRIFLUORO-BENZOYL FLUORIDE AND INTERMEDIATE PRODUCTS FOR THE PRODUCTION THEREOF | BAYER AKTIENGESELLSCHAFT (DE) | 1998-10-29 | — | — | WO | disclosed |
| WO-1998026779-A1 | THE USE OF 7-(2-OXA-5,8-DIAZABICYCLO[4.3.0]NON-8-YL)-QUINOLONE CARBOXYLIC ACID AND NAPHTHYRIDON CARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT OF HELICOBACTER PYLORI INFECTIONS AND ASSOCIATED GASTRODUODENAL DISEASES | BAYER AKTIENGESELLSCHAFT (DE) | 1998-06-25 | — | — | WO | disclosed |
| WO-1998026768-A2 | USE OF 7-(1-AMINOMETHYL-2-OXA-7-AZA-BICYCLO[3.3.0]OCT-7-YL)-QUINOLONE CARBOXYLIC ACID AND NAPHTHYRIDONE CARBOXYLIC ACID DERIVATIVES FOR TREATING HELICOBACTER PYLORI INFECTIONS AND THE GASTRODUODENAL DISEASES ASSOCIATED THEREWITH | BAYER AKTIENGESELLSCHAFT (DE) | 1998-06-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040167350-A1 | Bichlorinated compounds formed under with carboxy groupand elimation of water | CLIC4, AFF4, CBR1 | KEAP1 942/4885NFE2L2 1010/4885CYP3A4 65/4885 |
| US-20010023300-A1 | Preparing by reacting 3-cyano-2,4-dichloro-4-fluoro-benzoyl chloride nucleophilically with a fluoridizing agent; forming 3-cyano-2,4,5-trifluoro-benzoyl chloride from title compound; intermediates to antiinfective quinolonecarboxylic acids | CLIC4, AFF4, CBR1 | KEAP1 75/4885NFE2L2 119/4885CYP3A4 48/4885 |
| US-20030092929-A1 | Using halogenated xylene compound; chemical intermediate for quinolone antibiotics | CLIC4, FLI1, AFF4 | KEAP1 212/4885NFE2L2 402/4885CYP3A4 22/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.