Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.66 |
| ▸ | MAPT | P10636 | 2/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.62 |
| ▸ | GAA | P10253 | 3/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | CASP1 | P29466 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | ALPL | P05186 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25450202 | 1.00 | ALDH1A1 (0.66) | ALDH1A1MAPTSMN1; SMN2KMT2AGAA | |
| SCHEMBL25450154 | 0.89 | SMN1; SMN2 (0.56) | ALDH1A1MAPTSMN1; SMN2KMT2AGAA | |
| SCHEMBL30161390 | 0.89 | SMN1; SMN2 (0.56) | ALDH1A1MAPTSMN1; SMN2KMT2AGAA | |
| SCHEMBL30161354 | 0.88 | NPC1 (0.62) | ALDH1A1MAPTSMN1; SMN2KMT2ANPSR1 | |
| SCHEMBL25450199 | 0.88 | SMN1; SMN2 (0.59) | ALDH1A1MAPTSMN1; SMN2KMT2AGAA | |
| SCHEMBL25450006 | 0.88 | NPC1 (0.62) | ALDH1A1MAPTSMN1; SMN2KMT2ANPSR1 | |
| SCHEMBL30161358 | 0.85 | ALPL (0.51) | ALDH1A1MAPTSMN1; SMN2KMT2AGAA | |
| SCHEMBL25450208 | 0.85 | ALPL (0.51) | ALDH1A1MAPTSMN1; SMN2KMT2AGAA | |
| SCHEMBL25450174 | 0.80 | KEAP1 (0.60) | ALDH1A1MAPTSMN1; SMN2KMT2AMAPK1 | |
| SCHEMBL30161175 | 0.80 | KEAP1 (0.60) | ALDH1A1MAPTSMN1; SMN2KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115768750-A | GCN2 modulator compounds | 阿莱斯塔治疗公司 | 2023-03-07 | — | — | CN | disclosed |
| EP-4107146-A1 | GCN2 MODULATOR COMPOUNDS | Alesta Therapeutics BV (NL) | 2022-12-28 | — | — | EP | disclosed |