Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.51 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.47 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25450361 | 1.00 | LMNA (0.59) | LMNAALDH1A1KDM4EHTTKMT2A | |
| SCHEMBL25450174 | 0.94 | KEAP1 (0.60) | LMNAALDH1A1KDM4EHTTKMT2A | |
| SCHEMBL30161175 | 0.94 | KEAP1 (0.60) | LMNAALDH1A1KDM4EHTTKMT2A | |
| SCHEMBL30161490 | 0.89 | ALDH1A1 (0.57) | LMNAALDH1A1KDM4EHTTKMT2A | |
| SCHEMBL25450191 | 0.89 | ALDH1A1 (0.57) | LMNAALDH1A1KDM4EHTTKMT2A | |
| SCHEMBL25450395 | 0.88 | ALDH1A1 (0.63) | LMNAALDH1A1KDM4EHTTKMT2A | |
| SCHEMBL25450333 | 0.85 | CYP2D6 (0.43) | LMNAALDH1A1KDM4EHTTKMT2A | |
| SCHEMBL30161512 | 0.83 | GLO1 (0.49) | LMNAALDH1A1HTTKMT2AKEAP1 | |
| SCHEMBL25450289 | 0.83 | GLO1 (0.49) | LMNAALDH1A1HTTKMT2AKEAP1 | |
| SCHEMBL25450445 | 0.82 | TSHR (0.63) | ALDH1A1KDM4EHTTKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115768750-A | GCN2 modulator compounds | 阿莱斯塔治疗公司 | 2023-03-07 | — | — | CN | disclosed |
| EP-4107146-A1 | GCN2 MODULATOR COMPOUNDS | Alesta Therapeutics BV (NL) | 2022-12-28 | — | — | EP | disclosed |