SCHEMBL3016301

SCHEMBL3016301

CCCCCCN1C(=O)C(C(=O)NN)c2ccccc21

nearest known ligand 0.60

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CDC25A P30304 12/20 0.60
ALDH1A1 P00352 2/20 0.55
MEN1 O00255 1/20 0.55
KMT2A Q03164 1/20 0.55
HSD17B10 Q99714 1/20 0.55
CNR2 P34972 3/20 0.50
CNR1 P21554 1/20 0.50
SCN9A Q15858 1/20 0.48
CES1 P23141 2/20 0.44
EGFR P00533 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10632834 0.85 CDC25A (0.62) CDC25AALDH1A1MEN1KMT2AHSD17B10
SCHEMBL2823271 0.80 ALDH1A1 (0.59) ALDH1A1MEN1KMT2AHSD17B10EGFR
SCHEMBL1129549 0.77 CDC25A (0.80) CDC25AALDH1A1MEN1KMT2AHSD17B10
SCHEMBL3026352 0.76 CCKBR (0.45) ALDH1A1MEN1KMT2AHSD17B10EGFR
SCHEMBL29131197 0.76 CDC25A (0.60) CDC25AALDH1A1MEN1KMT2AHSD17B10
SCHEMBL7099245 0.76 EGFR (0.40) ALDH1A1MEN1KMT2AHSD17B10EGFR
SCHEMBL4595442 0.75 ALDH1A1 (0.75) CDC25AALDH1A1MEN1KMT2AHSD17B10
SCHEMBL28227485 0.75 CDC25A (0.62) CDC25AALDH1A1MEN1KMT2AHSD17B10
Hydrochloric Acid SCHEMBL7497399 0.75 CDC25A (0.59) CDC25AALDH1A1MEN1KMT2AHSD17B10
SCHEMBL14154017 0.72 HDAC4 (0.73) MEN1KMT2AEGFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180200225-A1 HYDRAZONE MODULATORS OF CANNABINOID RECEPTORS BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2018-07-19 US disclosed
US-20170231953-A1 HYDRAZONE MODULATORS OF CANNABINOID RECEPTORS CLEVELAND CLINIC FOUND (US) 2017-08-17 US disclosed
US-9656957-B2 Hydrazone modulators of cannabinoid receptors THE CLEVELAND CLINIC FOUNDATION (US) 2017-05-23 US disclosed
US-20150313874-A1 HYDRAZONE MODULATORS OF CANNABINOID RECEPTORS BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2015-11-05 US disclosed
US-9079854-B2 Hydrazone modulators of cannabinoid receptors THE CLEVELAND CLINIC FOUNDATION (US) 2015-07-14 US disclosed
US-20130184275-A1 HYDRAZONE MODULATORS OF CANNABINOID RECEPTORS BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2013-07-18 US disclosed
US-8309595-B2 Hydrazone modulators of cannabinoid receptors BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2012-11-13 US disclosed
US-20100197755-A1 HYDRAZONE MODULATORS OF CANNABINOID RECEPTORS BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2010-08-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170231953-A1 HYDRAZONE MODULATORS OF CANNABINOID RECEPTORS CNR1, CNR2, GPR18 CDC25A 2577/4885ALDH1A1 2096/4885MEN1 4169/4885
US-20150313874-A1 HYDRAZONE MODULATORS OF CANNABINOID RECEPTORS CNR1, CNR2, GPR18 CDC25A 2577/4885ALDH1A1 2096/4885MEN1 4169/4885
US-20100197755-A1 HYDRAZONE MODULATORS OF CANNABINOID RECEPTORS CNR1, CNR2, GPR18 CDC25A 2577/4885ALDH1A1 2096/4885MEN1 4169/4885
US-20130184275-A1 HYDRAZONE MODULATORS OF CANNABINOID RECEPTORS CNR1, CNR2, GPR18 CDC25A 2577/4885ALDH1A1 2096/4885MEN1 4169/4885
US-20180200225-A1 HYDRAZONE MODULATORS OF CANNABINOID RECEPTORS CNR1, CNR2, GPR18 CDC25A 2577/4885ALDH1A1 2096/4885MEN1 4169/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.