Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 7/20 | 0.54 |
| ▸ | MYC | P01106 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | XDH | P47989 | 1/20 | 0.33 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | CGAS | Q8N884 | 1/20 | 0.31 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22802381 | 1.00 | NLRP3 (0.54) | NLRP3MYCALDH1A1KDM4EMEN1 | |
| SCHEMBL29691325 | 0.85 | NLRP3 (0.42) | NLRP3ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL23012413 | 0.85 | NLRP3 (0.42) | NLRP3ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL29757351 | 0.85 | NLRP3 (0.42) | NLRP3ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL22802360 | 0.85 | NLRP3 (0.59) | NLRP3MYCALDH1A1XDHSLC22A12 | |
| SCHEMBL22802385 | 0.84 | NLRP3 (0.55) | NLRP3ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL29492920 | 0.84 | NLRP3 (0.55) | NLRP3ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL22867121 | 0.84 | NLRP3 (0.40) | NLRP3ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL22802375 | 0.84 | NLRP3 (0.59) | NLRP3MYCXDHSLC22A12CGAS | |
| Trifluoroacetic Acid SCHEMBL30163273 | 0.82 | NLRP3 (0.55) | NLRP3MYCXDHSLC22A12CGAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12030879-B2 | Sulfonyl acetamides as NLRP3 inhibitors | INFLAZOME LIMITED (IE) | 2024-07-09 | — | — | US | disclosed |
| US-11884645-B2 | Sulfonyl acetamides as NLRP3 inhibitors | INFLAZOME LIMITED (IE) | 2024-01-30 | — | — | US | disclosed |
| US-11834433-B2 | Compounds | INFLAZOME LIMITED (IE) | 2023-12-05 | — | — | US | disclosed |
| US-11530200-B2 | Compounds | INFLAZOME LIMITED (IE) | 2022-12-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12030879-B2 | Sulfonyl acetamides as NLRP3 inhibitors | NLRP3, NOD1, NLRP1 | NLRP3 1/4885MYC 4225/4885ALDH1A1 1078/4885 |
| US-11884645-B2 | Sulfonyl acetamides as NLRP3 inhibitors | NLRP3, NOD1, ABCC5 | NLRP3 1/4885MYC 4177/4885ALDH1A1 966/4885 |
| US-11834433-B2 | Compounds | NLRP3, NOD1, PYCARD | NLRP3 1/4885MYC 2519/4885ALDH1A1 378/4885 |
| US-11530200-B2 | Compounds | NLRP3, NOD1, NLRP1 | NLRP3 1/4885MYC 2959/4885ALDH1A1 1220/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.