Proctolin

SCHEMBL30163458

CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)[C@@H](C)O

nearest known ligand 0.71

Predicted protein targets (top 5)

	gene	UniProt	supporting neighbours	confidence
▸	NTSR1	P30989	14/20	0.71

▸	NTSR2	O95665	12/20	0.71

▸	SORT1	Q99523	9/20	0.71

▸	NMUR2	Q9GZQ4	1/20	0.63

▸	NMUR1	Q9HB89	1/20	0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Proctolin SCHEMBL14050093	0.89	NTSR2 (0.59)	NTSR1NTSR2SORT1
SCHEMBL30472155	0.87	NTSR1 (0.87)	NTSR1NTSR2SORT1
SCHEMBL29398203	0.87	NTSR1 (0.87)	NTSR1NTSR2SORT1
SCHEMBL29416842	0.87	NTSR1 (0.87)	NTSR1NTSR2SORT1
SCHEMBL32660794	0.86	NTSR1 (0.71)	NTSR1NTSR2SORT1NMUR2NMUR1
SCHEMBL31280899	0.85	NTSR1 (0.74)	NTSR1NTSR2SORT1
SCHEMBL29519178	0.83	NMUR2 (0.79)	NTSR1NTSR2NMUR2NMUR1
SCHEMBL29479234	0.82	NTSR1 (0.66)	NTSR1NTSR2SORT1NMUR2NMUR1
SCHEMBL29733484	0.82	NTSR1 (0.69)	NTSR1NTSR2SORT1NMUR2NMUR1
SCHEMBL30788019	0.81	SLC6A2 (0.68)	NMUR2NMUR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-3669879-B1	PHARMACEUTICAL COMPOSITION IN THE FORM OF AN ORAL SUSPENSION INCLUDING A FLAVONOID FRACTION COMPRISING DIOSMIN AND XANTHAN GUM	SERVIER LAB (FR)	2024-02-28	—	—	EP	disclosed
US-20220338471-A1	HONEY BEE-SAFE ACARICIDAL COMPOUNDS	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2022-10-27	—	—	US	disclosed