Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.64 |
| ▸ | CA9 | Q16790 | 1/20 | 0.64 |
| ▸ | INMT | O95050 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.36 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL5166062 | 1.00 | CA1 (0.64) | CA1CA9INMTTSHRTP53 | |
| Fumaric Acid SCHEMBL30153854 | 1.00 | CA1 (0.64) | CA1CA9INMTTSHRTP53 | |
| SCHEMBL18045659 | 0.91 | CA1 (0.57) | CA1CA9INMTTSHRTP53 | |
| Crotonic Acid SCHEMBL28618133 | 0.89 | CA1 (0.55) | CA1CA9INMTTSHRTP53 | |
| Bicarbonate SCHEMBL8606312 | 0.87 | CA1 (0.76) | CA1CA9TSHRTP53ALDH1A1 | |
| Hydrogen Peroxide SCHEMBL27660851 | 0.87 | CA1 (0.84) | CA1CA9TSHRTP53ALDH1A1 | |
| Acrylic Acid SCHEMBL28693697 | 0.86 | CA1 (0.61) | CA1CA9TSHRTP53ALDH1A1 | |
| Acrylic Acid SCHEMBL111449 | 0.86 | CA1 (0.61) | CA1CA9TSHRTP53ALDH1A1 | |
| Acrylic Acid SCHEMBL30598695 | 0.86 | CA1 (0.61) | CA1CA9TSHRTP53ALDH1A1 | |
| Acrylic Acid SCHEMBL9250354 | 0.86 | CA1 (0.61) | CA1CA9TSHRTP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 233 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10717813-B2 | Photocrosslinkable poly(caprolactone fumarate) | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2020-07-21 | — | — | US | claimed |
| EP-2967665-B1 | MODULAR TISSUE SCAFFOLDS | TISSUE REGENERATION SYSTEMS INC (US) | 2020-03-25 | — | — | EP | claimed |
| EP-2680771-B1 | DEGRADABLE CAGE FOR BONE FUSION | TISSUE REGENERATION SYSTEMS INC (US) | 2019-06-19 | — | — | EP | claimed |
| US-20190001025-A1 | BIODEGRADABLE SCAFFOLDS | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2019-01-03 | — | — | US | claimed |
| US-10058633-B2 | Biodegradable scaffolds | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2018-08-28 | — | — | US | claimed |
| US-9943410-B2 | Modular tissue scaffolds | DePuy Synthes Products, Inc. (US) | 2018-04-17 | — | — | US | claimed |
| US-9675358-B2 | Conduit for peripheral nerve replacement | WAKE FOREST UNIVERSITY HEALTH SCIENCES (US) | 2017-06-13 | — | — | US | claimed |
| US-20170136154-A1 | BIODEGRADABLE SCAFFOLDS | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2017-05-18 | — | — | US | claimed |
| EP-2967665-A1 | MODULAR TISSUE SCAFFOLDS | Tissue Regeneration Systems, Inc. (US) | 2016-01-20 | — | — | EP | claimed |
| EP-2838607-A1 | DESIGN OF A CONDUIT FOR PERIPHERAL NERVE REPLACEMENT | Wake Forest University Health Sciences (US) | 2015-02-25 | — | — | EP | claimed |
| EP-1874525-B1 | HYDROPHILIC/HYDROPHOBIC POLYMER NETWORKS BASED ON POLY(CAPROLACTONE FUMARATE), POLY(ETHYLENE GLYCOL FUMARATE), AND COPOLYMERS THEREOF | MAYO FOUNDATION (US) | 2011-06-01 | — | — | EP | claimed |
| EP-1874525-A4 | HYDROPHILIC/HYDROPHOBIC POLYMER NETWORKS BASED ON POLY(CAPROLACTONE FUMARATE), POLY(ETHYLENE GLYCOL FUMARATE), AND COPOLYMERS THEREOF | MAYO FOUNDATION (US) | 2009-05-27 | — | — | EP | claimed |
| EP-1664168-B1 | HYDROGEL POROGENS FOR FABRICATING BIODEGRADABLE SCAFFOLDS | MAYO FOUNDATION (US) | 2008-12-03 | — | — | EP | claimed |
| US-20080262102-A1 | Biodegradable polymer scaffolds for skeletal reconstruction; hydrogels with controllable hydrophilicity, swelling, mechanical properties; biocompatible, bioresorbable, injectable, and in-situ hardening; tissue engineering and controlled drug release; photocrosslinking; surgerical handling/positioning | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH | 2008-10-23 | — | — | US | claimed |
| US-20080206308-A1 | Hydrogel Porogents for Fabricating Biodegradable Scaffolds | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2008-08-28 | — | — | US | claimed |
| EP-1874525-A1 | HYDROPHILIC/HYDROPHOBIC POLYMER NETWORKS BASED ON POLY(CAPROLACTONE FUMARATE), POLY(ETHYLENE GLYCOL FUMARATE), AND COPOLYMERS THEREOF | Mayo Foundation for Medical Education and Research (US) | 2008-01-09 | — | — | EP | claimed |
| WO-2006118987-A1 | HYDROPHILIC/HYDROPHOBIC POLYMER NETWORKS BASED ON POLY(CAPROLACTONE FUMARATE), POLY(ETHYLENE GLYCOL FUMARATE), AND COPOLYMERS THEREOF | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2006-11-09 | — | — | WO | claimed |
| EP-1664168-A4 | HYDROGEL POROGENS FOR FABRICATING BIODEGRADABLE SCAFFOLDS | MAYO FOUNDATION (US) | 2006-09-13 | — | — | EP | claimed |
| EP-1664168-A2 | HYDROGEL POROGENS FOR FABRICATING BIODEGRADABLE SCAFFOLDS | Mayo Foundation for Medical Education and Research (US) | 2006-06-07 | — | — | EP | claimed |
| WO-2005020849-A2 | HYDROGEL POROGENS FOR FABRICATING BIODEGRADABLE SCAFFOLDS | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2005-03-10 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080262102-A1 | Biodegradable polymer scaffolds for skeletal reconstruction; hydrogels with controllable hydrophilicity, swelling, mechanical properties; biocompatible, bioresorbable, injectable, and in-situ hardening; tissue engineering and controlled drug release; photocrosslinking; surgerical handling/positioning | PLOD1, CPT1B, PLOD3 | MEN1 4130/4885KMT2A 4803/4885CA1 2126/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.