Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | DAO | P14920 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | IKBKB | O14920 | 2/20 | 0.34 |
| ▸ | XDH | P47989 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | NQO2 | P16083 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23900502 | 0.86 | HCAR2 (0.40) | MAPTPARP1DAOTSHRGPR84 | |
| SCHEMBL23907987 | 0.72 | FAAH (0.43) | MAPTGAAMAPK1 | |
| SCHEMBL23900441 | 0.69 | P2RX7 (0.42) | MAPT | |
| SCHEMBL23863964 | 0.67 | POLB (0.36) | MAPTLMNAPOLBL3MBTL1GAA | |
| SCHEMBL3708249 | 0.65 | LMNA (0.37) | PARP1LMNADAOPOLBL3MBTL1 | |
| SCHEMBL6366504 | 0.64 | HCAR2 (0.66) | DAO | |
| SCHEMBL2791167 | 0.64 | ALDH1A1 (0.56) | MAPTLMNAPOLBL3MBTL1KDM4E | |
| SCHEMBL13995850 | 0.64 | HCAR2 (0.47) | — | |
| SCHEMBL22186341 | 0.62 | PDE3B (0.45) | MAPTPARP1DAOPOLBXDH | |
| SCHEMBL16738661 | 0.62 | PDE2A (0.49) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4125845-A1 | NOVEL 2-PYRIMIDONE ANALOGS AS POTENT ANTIVIRAL AGENTS AGAINST ALPHAVIRUSES | Southern Research Institute (US) | 2023-02-08 | — | — | EP | disclosed |