Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 4/20 | 0.32 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.32 |
| ▸ | HTR3B | O95264 | 1/20 | 0.32 |
| ▸ | HTR3A | P46098 | 1/20 | 0.32 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30168080 | 0.84 | MAOB (0.44) | HTR2AHTR2CCYP1A2CYP2A6PRMT5 | |
| SCHEMBL29599854 | 0.82 | BIRC5 (0.41) | HTR2AHTR2CCYP2A6KDM4EALDH1A1 | |
| SCHEMBL6840186 | 0.78 | RXRA (0.48) | KDM4EALDH1A1HPGDHSD17B10HSP90AA1 | |
| SCHEMBL28842644 | 0.77 | KCNH2 (0.40) | KCNH2HTR2AHTR2CCYP1A2CYP2A6 | |
| SCHEMBL31116776 | 0.77 | DOT1L (0.41) | KCNH2HTR2AHTR2CCYP1A2CYP2A6 | |
| SCHEMBL31454908 | 0.77 | HTR2A (0.41) | KCNH2HTR2AHTR2CCYP1A2CYP2A6 | |
| SCHEMBL30168076 | 0.75 | HTR2A (0.37) | HTR2AHTR2CCYP1A2CYP2A6PRMT5 | |
| SCHEMBL415610 | 0.73 | KCNH2 (0.55) | KCNH2HTR2AHTR2CCYP1A2CYP2A6 | |
| SCHEMBL27580752 | 0.67 | KCNH2 (0.35) | KCNH2HTR2AHTR2CKDM4EALDH1A1 | |
| SCHEMBL5716071 | 0.67 | BIRC5 (0.42) | CYP1A2CYP2A6KDM4EALDH1A1CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115536662-A | Guanyl structure-containing tetracyclic indole compound, and synthesis method and application thereof | 广州大学 | 2022-12-30 | — | — | CN | disclosed |