Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | PREP | P48147 | 1/20 | 0.38 |
| ▸ | FAP | Q12884 | 1/20 | 0.38 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.38 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CASP6 | P55212 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | RXRB | P28702 | 1/20 | 0.33 |
| ▸ | RXRG | P48443 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1665412 | 0.80 | RXRA (0.48) | POLBCASP6RXRARXRBRXRG | |
| SCHEMBL30168656 | 0.79 | CA12 (0.33) | CA12CA1CA2CA9CA14 | |
| SCHEMBL979202 | 0.77 | ALDH1A1 (0.41) | DPP4PREPFAPDPP8DPP9 | |
| SCHEMBL13125270 | 0.77 | PLAU (0.56) | MAPTPOLBCA12CA1CA2 | |
| SCHEMBL19556499 | 0.77 | MAPT (0.57) | MAPTL3MBTL1NAPRT | |
| SCHEMBL23166949 | 0.77 | TSHR (0.58) | MAPTPOLBCASP6CA12CA1 | |
| SCHEMBL19438931 | 0.76 | L3MBTL1 (0.47) | MAPTPOLBCA12CA1CA2 | |
| SCHEMBL2714328 | 0.76 | TSHR (0.51) | DPP4PREPFAPDPP8DPP9 | |
| SCHEMBL2803417 | 0.76 | L3MBTL1 (0.44) | DPP4PREPFAPDPP8DPP9 | |
| SCHEMBL24987096 | 0.75 | MEN1 (0.44) | MAPTPOLBL3MBTL1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022266069-A1 | TRICYCLIC KRAS G12D INHIBITORS | ERASCA, INC. (US) | 2022-12-22 | — | — | WO | disclosed |