Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.34 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.33 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.32 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.32 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.32 |
| ▸ | KDR | P35968 | 2/20 | 0.32 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.32 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.31 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.31 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.31 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.31 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30170870 | 0.81 | ELANE (0.39) | ELANETRPV1EPHA2KDREPHB4 | |
| SCHEMBL30170824 | 0.78 | SOS1 (0.35) | ELANETRPV1CCNT1CDK9SOS1 | |
| SCHEMBL30170868 | 0.78 | ALOX5 (0.38) | ELANETRPV1EPHA2KDREPHB4 | |
| SCHEMBL21667913 | 0.63 | TSHR (0.50) | — | |
| SCHEMBL30170681 | 0.62 | DHODH (0.42) | ELANEEPHA2KDREPHB4PDGFRB | |
| SCHEMBL30170771 | 0.62 | ELANE (0.41) | ELANEEPHA2KDREPHB4PDGFRB | |
| SCHEMBL30170858 | 0.60 | ALOX5 (0.39) | ELANEEPHA2KDREPHB4PDGFRB | |
| SCHEMBL30170830 | 0.60 | ALOX5 (0.39) | ELANEEPHA2KDREPHB4PDGFRB | |
| SCHEMBL24753239 | 0.60 | KDM1A (0.39) | — | |
| SCHEMBL14729710 | 0.60 | CNR1 (0.41) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022262691-A1 | HETEROCYCLIC COMPOUNDS AS SOS1 INHIBITORS | BEIJING INNOCARE PHARMA TECH CO., LTD. (CN) | 2022-12-22 | — | — | WO | disclosed |