Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30170681 | 0.86 | DHODH (0.42) | ELANEPDGFRBPDGFRADHODHNTSR1 | |
| SCHEMBL24791336 | 0.82 | AXL (0.37) | ELANEALOX5HTR2AKDRNQO2 | |
| SCHEMBL30170870 | 0.80 | ELANE (0.39) | ELANEPDGFRBPDGFRADHODHNTSR1 | |
| SCHEMBL30170858 | 0.77 | ALOX5 (0.39) | ELANEPDGFRBPDGFRAALOX5DHODH | |
| SCHEMBL15819502 | 0.76 | NTSR1 (0.59) | ELANEALOX5NTSR1PDE3BPDE3A | |
| SCHEMBL24791028 | 0.71 | PDE4A (0.49) | ALOX5PDE3BPDE3AMEN1KMT2A | |
| SCHEMBL19385357 | 0.71 | ELANE (0.55) | ELANEPDGFRBPDGFRAPDE3BPDE3A | |
| SCHEMBL5532256 | 0.70 | SMN1; SMN2 (0.45) | ELANEMAPTHTR2AL3MBTL1HTR2C | |
| SCHEMBL15502326 | 0.69 | ELANE (0.53) | ELANEPDGFRBPDGFRAABCB1NSD2 | |
| SCHEMBL15819106 | 0.67 | NTSR1 (0.49) | ELANENTSR1PDE3BPDE3AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022262691-A1 | HETEROCYCLIC COMPOUNDS AS SOS1 INHIBITORS | BEIJING INNOCARE PHARMA TECH CO., LTD. (CN) | 2022-12-22 | — | — | WO | disclosed |