Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.39 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.38 |
| ▸ | CSNK2B | P67870 | 3/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.38 |
| ▸ | F7 | P08709 | 1/20 | 0.37 |
| ▸ | F3 | P13726 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | PRKAB2 | O43741 | 3/20 | 0.33 |
| ▸ | PRKAG1 | P54619 | 3/20 | 0.33 |
| ▸ | PRKAA2 | P54646 | 3/20 | 0.33 |
| ▸ | PRKAA1 | Q13131 | 3/20 | 0.33 |
| ▸ | PRKAG3 | Q9UGI9 | 3/20 | 0.33 |
| ▸ | PRKAG2 | Q9UGJ0 | 3/20 | 0.33 |
| ▸ | PRKAB1 | Q9Y478 | 3/20 | 0.33 |
| ▸ | KDM3B | Q7LBC6 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3028817 | 0.79 | NR4A2 (0.43) | PBRM1BRPF1 | |
| SCHEMBL1396183 | 0.75 | NOTUM (0.47) | CSNK2A2CSNK2BCSNK2A1DYRK1ANOTUM | |
| SCHEMBL3553024 | 0.74 | CSNK2A2 (0.38) | CSNK2A2CSNK2BCSNK2A1F7F3 | |
| SCHEMBL21060959 | 0.72 | GABRA1 (0.41) | HSD17B10TSHR | |
| SCHEMBL3030002 | 0.72 | NR4A2 (0.43) | CSNK2A2CSNK2BCSNK2A1F7F3 | |
| SCHEMBL13983016 | 0.68 | KDM4E (0.49) | KDM4EHSD17B10TSHR | |
| SCHEMBL6023948 | 0.68 | NOTUM (0.46) | CSNK2A2CSNK2BCSNK2A1F7F3 | |
| SCHEMBL3023164 | 0.68 | ERN1 (0.33) | CSNK2A2CSNK2BCSNK2A1F7F3 | |
| SCHEMBL24890364 | 0.67 | NOTUM (0.38) | BRPF1NOTUMKDM4EHSD17B10 | |
| SCHEMBL5674660 | 0.66 | KDM4E (0.41) | CSNK2A2CSNK2BCSNK2A1F7F3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304419-B2 | Chemical compounds | GLAXOSMITHKLINE LLC (US) | 2012-11-06 | — | — | US | disclosed |
| US-20100216746-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216746-A1 | CHEMICAL COMPOUNDS | SAMHD1, POLRMT, NUDT1 | PBRM1 2272/4885CSNK2A2 3843/4885CSNK2B 4068/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.