Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.32 |
| ▸ | CTSD | P07339 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.31 |
| ▸ | RET | P07949 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
| ▸ | PI4KA | P42356 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.31 |
| ▸ | BMPR1A | P36894 | 2/20 | 0.31 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.31 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.31 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23622964 | 0.85 | KDM5A (0.36) | KDM5ARETPIK3CDPIK3CAPIK3CB | |
| SCHEMBL25882396 | 0.84 | IRAK4 (0.39) | KDM5AGSK3BDYRK1AALOX15IRAK4 | |
| SCHEMBL30173410 | 0.82 | ACHE (0.35) | KDM5AGSK3BDYRK1AACHE | |
| SCHEMBL30173406 | 0.82 | FGFR1 (0.35) | KDM5AGSK3BDYRK1AACVR1 | |
| SCHEMBL28214771 | 0.81 | KDM5A (0.38) | KDM5ARETPIK3CDPIK3CAPIK3CB | |
| SCHEMBL216558 | 0.79 | ALOX15 (0.50) | KDM5AGSK3BDYRK1AALOX15EGFR | |
| SCHEMBL30173405 | 0.78 | ACHE (0.34) | KDM5AIRAK4METALKACHE | |
| SCHEMBL173506 | 0.78 | — | — | |
| SCHEMBL17076859 | 0.78 | GSK3B (0.38) | KDM5AGSK3BDYRK1AIRAK4RET | |
| Hydrochloric Acid SCHEMBL15145595 | 0.78 | ALOX15 (0.49) | KDM5AGSK3BDYRK1AALOX15EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112771032-B | Pyrimidine pyrazole compounds as fourth generation EGFR inhibitors | 江苏先声药业有限公司 | 2023-01-03 | — | — | CN | disclosed |