Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 15/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 14/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 14/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.31 |
| ▸ | KDM5A | P29375 | 1/20 | 0.31 |
| ▸ | IGF1R | P08069 | 1/20 | 0.31 |
| ▸ | WNT1 | P04628 | 1/20 | 0.30 |
| ▸ | GSK3B | P49841 | 1/20 | 0.30 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30173410 | 0.84 | ACHE (0.35) | KDM5AWNT1GSK3BDYRK1A | |
| SCHEMBL13727751 | 0.83 | FGFR1 (0.46) | FGFR1FGFR2FGFR3ACVR1KDM5A | |
| SCHEMBL30173403 | 0.82 | KDM5A (0.35) | ACVR1KDM5AGSK3BDYRK1A | |
| SCHEMBL30173405 | 0.78 | ACHE (0.34) | FGFR1FGFR2FGFR3KDM5A | |
| SCHEMBL23622964 | 0.77 | KDM5A (0.36) | ACVR1KDM5A | |
| SCHEMBL30173398 | 0.76 | KAT2B (0.35) | FGFR1FGFR2FGFR3HDAC2ACVR1 | |
| SCHEMBL28214771 | 0.72 | KDM5A (0.38) | ACVR1KDM5A | |
| SCHEMBL173506 | 0.70 | — | — | |
| SCHEMBL17076859 | 0.70 | GSK3B (0.38) | ACVR1KDM5AGSK3BDYRK1A | |
| SCHEMBL24327679 | 0.69 | ALDH1A1 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112771032-B | Pyrimidine pyrazole compounds as fourth generation EGFR inhibitors | 江苏先声药业有限公司 | 2023-01-03 | — | — | CN | disclosed |