Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.34 |
| ▸ | KDM5A | P29375 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.32 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30173410 | 0.83 | ACHE (0.35) | ACHEKDM5A | |
| SCHEMBL23622964 | 0.79 | KDM5A (0.36) | ACHEKDM5AMETALK | |
| SCHEMBL30173403 | 0.78 | KDM5A (0.35) | ACHEKDM5AMETALKIRAK4 | |
| SCHEMBL30173406 | 0.78 | FGFR1 (0.35) | KDM5AFGFR1FGFR2FGFR3 | |
| SCHEMBL17076859 | 0.74 | GSK3B (0.38) | ACHEKDM5AMETALKIRAK4 | |
| SCHEMBL28918261 | 0.72 | KDM5A (0.38) | ACHEKDM5AFGFR1FGFR2FGFR3 | |
| SCHEMBL173506 | 0.72 | — | — | |
| SCHEMBL28214771 | 0.71 | KDM5A (0.38) | ACHEKDM5AMETALK | |
| Hydrochloric Acid SCHEMBL31507950 | 0.70 | PIK3CD (0.41) | ACHEKDM5A | |
| Hydrochloric Acid SCHEMBL25243994 | 0.70 | PIK3CD (0.41) | ACHEKDM5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112771032-B | Pyrimidine pyrazole compounds as fourth generation EGFR inhibitors | 江苏先声药业有限公司 | 2023-01-03 | — | — | CN | disclosed |