Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMOX1 | P09601 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL28799633 | 1.00 | HMOX1 (0.37) | HMOX1USP2ALDH1A1LMNAALOX15 | |
| SCHEMBL21067 | 0.94 | HMOX1 (0.40) | HMOX1 | |
| SCHEMBL6048041 | 0.93 | HMOX1 (0.40) | HMOX1 | |
| SCHEMBL9871901 | 0.85 | HMOX1 (0.42) | HMOX1TBXAS1 | |
| SCHEMBL8100581 | 0.76 | NAAA (0.38) | ALDH1A1LMNAALOX15HTT | |
| SCHEMBL9367733 | 0.75 | HMOX1 (0.38) | HMOX1 | |
| SCHEMBL9274736 | 0.71 | USP2 (0.36) | USP2ALDH1A1LMNAALOX15TSHR | |
| SCHEMBL9367613 | 0.66 | HMOX1 (0.40) | HMOX1TBXAS1 | |
| SCHEMBL11239949 | 0.64 | HMOX1 (0.61) | HMOX1 | |
| Acetic Acid SCHEMBL11261784 | 0.64 | HMOX1 (0.54) | HMOX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023112856-A1 | FUSED HETEROCYCLIC DERIVATIVE AND HERBICIDE CONTAINING SAME AS ACTIVE INGREDIENT | クミアイ化学工業株式会社 | 2023-06-22 | — | — | WO | disclosed |