Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 9/20 | 0.51 |
| ▸ | DRD3 | P35462 | 8/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | HTR1D | P28221 | 2/20 | 0.48 |
| ▸ | HTR1B | P28222 | 2/20 | 0.48 |
| ▸ | DRD4 | P21917 | 2/20 | 0.44 |
| ▸ | PYGL | P06737 | 1/20 | 0.43 |
| ▸ | PYGM | P11217 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.41 |
| ▸ | KDM4D | Q6B0I6 | 2/20 | 0.40 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28578331 | 1.00 | DRD2 (0.51) | DRD2DRD3CYP2D6HTR1DHTR1B | |
| SCHEMBL28578333 | 1.00 | DRD2 (0.51) | DRD2DRD3CYP2D6HTR1DHTR1B | |
| SCHEMBL8713035 | 0.87 | DRD2 (0.49) | DRD2DRD3CYP2D6HTR1DHTR1B | |
| SCHEMBL8903628 | 0.87 | DRD2 (0.49) | DRD2DRD3CYP2D6HTR1DHTR1B | |
| SCHEMBL21822133 | 0.85 | DRD2 (0.53) | DRD2DRD3CYP2D6HTR1DHTR1B | |
| SCHEMBL15506758 | 0.82 | NPC1 (0.56) | DRD2DRD3CYP2D6HTR1DHTR1B | |
| SCHEMBL28588273 | 0.82 | PIN1 (0.51) | DRD2USP30SMYD3PARP1 | |
| SCHEMBL30180732 | 0.82 | PIN1 (0.51) | DRD2USP30SMYD3PARP1 | |
| SCHEMBL28588272 | 0.82 | PIN1 (0.51) | DRD2USP30SMYD3PARP1 | |
| SCHEMBL25016345 | 0.80 | RET (0.41) | DRD4RETKDRSMYD3MLLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3860636-B1 | MATRIPTASE 2 INHIBITORS AND USES THEREOF | DISC MEDICINE INC (US) | 2026-01-28 | — | — | EP | disclosed |
| US-12428415-B2 | Matriptase 2 inhibitors and uses thereof | DISC MEDICINE, INC. (US) | 2025-09-30 | — | — | US | disclosed |
| US-20230043159-A1 | MATRIPTASE 2 INHIBITORS AND USES THEREOF | DISC MEDICINE, INC. | 2023-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12428415-B2 | Matriptase 2 inhibitors and uses thereof | MMP7, MATR3, SPINT2 | DRD2 4828/4885DRD3 4796/4885CYP2D6 1642/4885 |
| US-20230043159-A1 | MATRIPTASE 2 INHIBITORS AND USES THEREOF | MMP7, MATR3, SPINT2 | DRD2 4828/4885DRD3 4796/4885CYP2D6 1642/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.