SCHEMBL30180862

SCHEMBL30180862

N=C(N)NCc1ccc(NC(=O)C23CC(C(=O)Nc4ccc(C5=CCN(C(=N)N)CC5)nn4)(C2)C3)cc1

nearest known ligand 0.33

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
WNT3A P56704 4/20 0.33
MAPT P10636 2/20 0.33
TP53 P04637 1/20 0.33
NPC1 O15118 2/20 0.32
ALDH1A1 P00352 1/20 0.32
ALOX15 P16050 1/20 0.32
TSHR P16473 1/20 0.32
RAB9A P51151 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
NAMPT P43490 9/20 0.32
KDM4E B2RXH2 1/20 0.32
MEN1 O00255 1/20 0.32
LMNA P02545 1/20 0.32
KMT2A Q03164 1/20 0.32
CA12 O43570 1/20 0.31
CA1 P00915 1/20 0.31
CA2 P00918 1/20 0.31
CA9 Q16790 1/20 0.31
CDK13 Q14004 1/20 0.30
CDK12 Q9NYV4 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24891674 0.95 WNT3A (0.34) WNT3AMAPTTP53NPC1ALDH1A1
SCHEMBL30180922 0.95 WNT3A (0.34) WNT3AMAPTTP53NPC1ALDH1A1
SCHEMBL30180918 0.88 TMPRSS2 (0.40) NPC1RAB9ASMN1; SMN2NAMPTKDM4E
SCHEMBL24892076 0.88 WNT3A (0.36) WNT3AMAPTTP53NAMPTCDK13
SCHEMBL24891721 0.87 NAMPT (0.31) WNT3AMAPTTP53NAMPT
SCHEMBL24891781 0.86 NPC1 (0.41) MAPTTP53NPC1ALDH1A1ALOX15
SCHEMBL24891727 0.84 WNT3A (0.34) WNT3AMAPTTP53NAMPTCDK13
SCHEMBL30180901 0.83 WNT3A (0.38) WNT3AMAPTTP53NAMPTCDK13
SCHEMBL24891824 0.83 WNT3A (0.38) WNT3AMAPTTP53NAMPTCDK13
SCHEMBL24891713 0.83 NPC1 (0.40) MAPTNPC1ALDH1A1ALOX15TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023287736-A1 NOVEL BIS-AMIDE CONTAINING COMPOUNDS EXHIBITING ANTIFUNGAL ACTIVITY AND THEIR METHOD OF USE FOX CHASE CHEMICAL DIVERSITY CENTER, INC. (US) 2023-01-19 WO claimed
WO-2023287736-A1 NOVEL BIS-AMIDE CONTAINING COMPOUNDS EXHIBITING ANTIFUNGAL ACTIVITY AND THEIR METHOD OF USE FOX CHASE CHEMICAL DIVERSITY CENTER, INC. (US) 2023-01-19 WO disclosed