Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.49 |
| ▸ | CNR2 | P34972 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | FAAH | O00519 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30098987 | 0.84 | ALDH1A1 (0.63) | GRM5ALDH1A1TSHRHPGDRAB9A | |
| SCHEMBL21413719 | 0.83 | GRM5 (0.67) | GRM5ALDH1A1TSHRHPGDMAPK1 | |
| SCHEMBL2468483 | 0.82 | NPC1 (0.71) | GRM5ALDH1A1TSHRHPGDMAPK1 | |
| SCHEMBL1667825 | 0.79 | RAB9A (0.73) | GRM5ALDH1A1TSHRHPGDMAPK1 | |
| SCHEMBL11241115 | 0.78 | RAB9A (0.75) | GRM5ALDH1A1TSHRHPGDMAPK1 | |
| SCHEMBL30804720 | 0.78 | GRM5 (0.60) | GRM5ALDH1A1TSHRMAPK1RAB9A | |
| SCHEMBL1711687 | 0.76 | ALDH1A1 (0.63) | GRM5ALDH1A1TSHRHPGDMAPK1 | |
| SCHEMBL29530916 | 0.76 | ALDH1A1 (0.63) | GRM5ALDH1A1TSHRHPGDMAPK1 | |
| SCHEMBL6455623 | 0.76 | SMYD3 (0.69) | GRM5ALDH1A1TSHRHPGDRAB9A | |
| SCHEMBL6455626 | 0.76 | SMYD3 (0.69) | GRM5ALDH1A1TSHRHPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4384510-A1 | COMPOUNDS TARGETING MUTANT OF P53 | Jacobio Pharmaceuticals Co., Ltd. (CN) | 2024-06-19 | — | — | EP | disclosed |
| CN-117813295-A | Compounds targeting p53 mutants | 北京加科思新药研发有限公司 | 2024-04-02 | — | — | CN | disclosed |
| WO-2023016434-A1 | COMPOUNDS TARGETING MUTANT OF P53 | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2023-02-16 | — | — | WO | disclosed |