Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 3/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | FAAH | O00519 | 1/20 | 0.53 |
| ▸ | CNR2 | P34972 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | HPGDS | O60760 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2468483 | 0.89 | NPC1 (0.71) | GRM5ALDH1A1TSHRNPC1MAPK1 | |
| SCHEMBL1667825 | 0.83 | RAB9A (0.73) | GRM5ALDH1A1TSHRNPC1MAPK1 | |
| SCHEMBL6455623 | 0.83 | SMYD3 (0.69) | GRM5ALDH1A1TSHRNPC1RAB9A | |
| SCHEMBL6455626 | 0.83 | SMYD3 (0.69) | GRM5ALDH1A1TSHRNPC1RAB9A | |
| SCHEMBL30184529 | 0.83 | GRM5 (0.61) | GRM5ALDH1A1TSHRNPC1MAPK1 | |
| SCHEMBL11241115 | 0.82 | RAB9A (0.75) | GRM5ALDH1A1TSHRNPC1MAPK1 | |
| SCHEMBL3663354 | 0.81 | ALDH1A1 (0.61) | GRM5ALDH1A1TSHRNPC1MAPK1 | |
| SCHEMBL1711687 | 0.80 | ALDH1A1 (0.63) | GRM5ALDH1A1TSHRNPC1MAPK1 | |
| SCHEMBL29530916 | 0.80 | ALDH1A1 (0.63) | GRM5ALDH1A1TSHRNPC1MAPK1 | |
| SCHEMBL30098987 | 0.80 | ALDH1A1 (0.63) | GRM5ALDH1A1TSHRNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10428080-B2 | TBK/IKK inhibitor compounds and uses thereof | MERCK PATENT GMBH (DE) | 2019-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10428080-B2 | TBK/IKK inhibitor compounds and uses thereof | NFKBIA, TBKBP1, TBK1 | GRM5 3854/4885ALDH1A1 4646/4885TSHR 3067/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.