Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 10/20 | 0.37 |
| ▸ | HRH1 | P35367 | 10/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 10/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | XBP1 | P17861 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | MPL | P40238 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.31 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29099527 | 1.00 | HRH2 (0.37) | HRH2HRH1HRH4HRH3MAPT | |
| SCHEMBL29099495 | 0.84 | HRH2 (0.36) | HRH2HRH1HRH4HRH3MAPT | |
| SCHEMBL29099501 | 0.72 | HRH2 (0.35) | HRH2HRH1HRH4HRH3MAPT | |
| SCHEMBL31544001 | 0.71 | PRMT6 (0.37) | HRH2HRH1HRH4HRH3MAPT | |
| SCHEMBL30185591 | 0.71 | HRH2 (0.36) | HRH2HRH1HRH4HRH3MAPT | |
| SCHEMBL29099535 | 0.71 | HRH2 (0.36) | HRH2HRH1HRH4HRH3MAPT | |
| SCHEMBL30935380 | 0.66 | PBRM1 (0.43) | LMNAMAPK1 | |
| SCHEMBL29099545 | 0.66 | PBRM1 (0.43) | LMNAMAPK1 | |
| SCHEMBL330359 | 0.65 | BRD4 (0.51) | HRH2HRH1HRH4HRH3ALDH1A1 | |
| SCHEMBL48693 | 0.64 | PIK3CD (0.65) | HRH2HRH1HRH4HRH3PIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115611883-A | PI3K alpha inhibitor with bicyclic structure and preparation method and application thereof | 生物岛实验室 | 2023-01-17 | — | — | CN | disclosed |