Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 3/20 | 0.33 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.33 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.31 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22615180 | 0.84 | APLNR (0.43) | — | |
| SCHEMBL29301529 | 0.82 | RAB9A (0.39) | CASP1MEN1MAPTKMT2A | |
| SCHEMBL22615141 | 0.81 | PTK2 (0.40) | P2RX3P2RX2CASP1MEN1KMT2A | |
| SCHEMBL21355063 | 0.81 | RAB9A (0.37) | MEN1MAPTKMT2A | |
| SCHEMBL30189323 | 0.81 | SMARCA2 (0.34) | — | |
| SCHEMBL27972595 | 0.78 | HDAC3 (0.39) | HPGDCASP1 | |
| SCHEMBL21355295 | 0.77 | CACNA1G (0.40) | CACNA1GCACNA1HCACNA1IKMT2A | |
| SCHEMBL9107644 | 0.77 | HDAC1 (0.41) | P2RX7HPGDP2RX3P2RX2CASP1 | |
| SCHEMBL9109370 | 0.75 | KCNQ3 (0.38) | KCNH2HPGDCASP1MEN1KMT2A | |
| SCHEMBL24586223 | 0.75 | CYP3A4 (0.41) | HPGDCASP1MEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4149945-A1 | SUBSTITUTED TRICYCLIC AMIDES, ANALOGUES THEREOF, AND METHODS USING SAME | Arbutus Biopharma Corporation (CA) | 2023-03-22 | — | — | EP | disclosed |